Detailed information of TA system TA118248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 137426..137973
• Replicon: chromosome
• Accession: NZ_CP035683
• Organism: Vibrio mimicus strain 2011V-1073

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0Q0PYS1
• Locus tag: ET951_RS15295
• Protein ID: WP_000229322.1
• Coordinates: 137671..137973 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: ET951_RS15290
• Protein ID: WP_000861987.1
• Coordinates: 137426..137683 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ET951_RS15245	132541..133041	-	501	WP_154113890.1	RloB domain-containing protein	-
ET951_RS15250	133056..134207	-	1152	WP_192927747.1	ATP-binding protein	-
ET951_RS15255	134407..134562	+	156	WP_154114451.1	DUF3265 domain-containing protein	-
ET951_RS15260	134574..134987	+	414	WP_000451539.1	GNAT family N-acetyltransferase	-
ET951_RS15265	135160..135573	+	414	WP_154114452.1	GFA family protein	-
ET951_RS15275	136029..136130	+	102	WP_081096080.1	acetyltransferase	-
ET951_RS15280	136120..136506	+	387	WP_192927746.1	VOC family protein	-
ET951_RS15285	136660..137214	+	555	WP_154113893.1	sugar O-acetyltransferase	-
ET951_RS15290	137426..137683	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ET951_RS15295	137671..137973	+	303	WP_000229322.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ET951_RS15300	138153..138962	+	810	WP_148546667.1	hypothetical protein	-
ET951_RS15305	139128..139679	+	552	WP_192927745.1	hypothetical protein	-
ET951_RS15310	139998..140137	+	140	Protein_183	DUF645 family protein	-
ET951_RS15315	140425..140757	-	333	WP_000039956.1	SEC-C domain-containing protein	-
ET951_RS15320	141044..141433	-	390	WP_154113819.1	hypothetical protein	-
ET951_RS15325	141444..141761	-	318	WP_154113820.1	hypothetical protein	-
ET951_RS15330	142134..142313	+	180	WP_154114453.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	54396..217049	162653
	-	inside	Integron	-	-	55591..210101	154510

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11737.67 Da
• Isoelectric Point: 5.1972

>T118248 WP_000229322.1 NZ_CP035683:137671-137973 [Vibrio mimicus]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T118248 NZ_CP035683:137671-137973 [Vibrio mimicus]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAATTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT118248 WP_000861987.1 NZ_CP035683:137426-137683 [Vibrio mimicus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT118248 NZ_CP035683:137426-137683 [Vibrio mimicus]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Structures

Toxin

• AlphaFold DB: A0A0Q0PYS1

Antitoxin

• AlphaFold DB: A0A1T4SLM9