Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2221813..2222372 Replicon chromosome
Accession NZ_CP035680
Organism Vibrio navarrensis strain 08-2462

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EWA66_RS11000 Protein ID WP_013571609.1
Coordinates 2221813..2222091 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EWA66_RS11005 Protein ID WP_013571610.1
Coordinates 2222088..2222372 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWA66_RS10965 2216977..2218101 + 1125 WP_154199795.1 ISAs1 family transposase -
EWA66_RS10970 2218234..2218383 - 150 WP_154199850.1 hypothetical protein -
EWA66_RS10975 2218563..2219324 + 762 WP_154199870.1 hypothetical protein -
EWA66_RS10980 2219985..2220320 + 336 WP_039444439.1 hypothetical protein -
EWA66_RS10985 2220361..2220450 + 90 WP_081947374.1 DUF3265 domain-containing protein -
EWA66_RS10990 2220481..2221059 + 579 WP_039444437.1 hypothetical protein -
EWA66_RS10995 2221204..2221674 + 471 WP_039444436.1 GNAT family N-acetyltransferase -
EWA66_RS11000 2221813..2222091 - 279 WP_013571609.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EWA66_RS11005 2222088..2222372 - 285 WP_013571610.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EWA66_RS11010 2222371..2222559 + 189 WP_152593426.1 DUF3265 domain-containing protein -
EWA66_RS11015 2222902..2223024 + 123 Protein_2066 DUF3265 domain-containing protein -
EWA66_RS11020 2223041..2223436 + 396 WP_039444434.1 hypothetical protein -
EWA66_RS11025 2223426..2223551 + 126 Protein_2068 DUF3265 domain-containing protein -
EWA66_RS11030 2223710..2223946 + 237 WP_033930507.1 DUF3709 domain-containing protein -
EWA66_RS11035 2224226..2224456 - 231 WP_152593424.1 hypothetical protein -
EWA66_RS11040 2225094..2225210 + 117 WP_081947376.1 DUF3265 domain-containing protein -
EWA66_RS11045 2225266..2225547 + 282 WP_154199872.1 hypothetical protein -
EWA66_RS11050 2225848..2225958 + 111 WP_154199952.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1923154..2273696 350542
- flank IS/Tn - - 2226711..2227526 815
- inside Integron - - 2199675..2264089 64414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10970.64 Da        Isoelectric Point: 4.3697

>T118245 WP_013571609.1 NZ_CP035680:c2222091-2221813 [Vibrio navarrensis]
MILWEEESLNDREKIFEFLHDFNPDAAERTDEIIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGDFIRIM
RVLHQKQKFPVD

Download         Length: 279 bp

>T118245 NZ_CP035680:c2222091-2221813 [Vibrio navarrensis]
ATGATTTTGTGGGAAGAAGAGTCTCTGAACGATCGTGAAAAGATCTTTGAGTTTCTTCATGATTTCAACCCTGACGCTGC
AGAAAGAACTGACGAGATCATCGAAACAAAAGTTGAAAACCTGTTAGAGCAACCTCTTATGGGGGTACAACGTGACGGGA
TCAGAGGGCGATTGCTCATCATTCCTGAAATATCGATGATCGTATCCTATTGGGTCGACGGTGACTTTATTCGCATAATG
CGTGTACTACACCAAAAGCAAAAGTTCCCGGTGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10937.36 Da        Isoelectric Point: 9.1865

>AT118245 WP_013571610.1 NZ_CP035680:c2222372-2222088 [Vibrio navarrensis]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKAVFVDHESAKVR
MAERKAKIRNRGKL

Download         Length: 285 bp

>AT118245 NZ_CP035680:c2222372-2222088 [Vibrio navarrensis]
ATGGACACCAGAATTCAGTTTCGTGTTGATGAAGAAACTAAACGACTAGCTCAACAAATGGCTGAAAGCCAAGGCAGAAC
ATTGAGTGATGCTTGCCGAGAATTGACTGAGCAACTAGCAGAACAACAGAGAAAGACCTTATCTCACGATGCATGGTTAA
CTGAACAAGTAAATTTGGCTTTTGAGAAGTTCGATTCAGGGAAAGCCGTTTTTGTTGACCACGAATCAGCAAAAGTTCGT
ATGGCCGAGCGCAAAGCTAAAATTCGCAACCGAGGCAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References