Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2185571..2186099 Replicon chromosome
Accession NZ_CP035680
Organism Vibrio navarrensis strain 08-2462

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag EWA66_RS10585 Protein ID WP_005377002.1
Coordinates 2185571..2185861 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag EWA66_RS10590 Protein ID WP_005377003.1
Coordinates 2185851..2186099 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWA66_RS20325 2180629..2180718 + 90 Protein_1969 DUF3265 domain-containing protein -
EWA66_RS10540 2180790..2181020 - 231 Protein_1970 PAS factor family protein -
EWA66_RS10545 2181133..2181222 + 90 Protein_1971 DUF3265 domain-containing protein -
EWA66_RS10550 2182271..2182519 + 249 WP_039444405.1 hypothetical protein -
EWA66_RS10555 2182994..2183122 + 129 WP_072616275.1 DUF3265 domain-containing protein -
EWA66_RS10560 2183487..2183588 + 102 WP_110178353.1 DUF3265 domain-containing protein -
EWA66_RS10565 2183613..2183912 + 300 WP_039445737.1 hypothetical protein -
EWA66_RS10570 2183996..2184454 - 459 WP_039445739.1 hypothetical protein -
EWA66_RS10575 2184674..2184766 + 93 WP_017789251.1 DUF3265 domain-containing protein -
EWA66_RS10580 2185424..2185552 + 129 WP_081946544.1 DUF3265 domain-containing protein -
EWA66_RS10585 2185571..2185861 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EWA66_RS10590 2185851..2186099 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EWA66_RS10595 2186616..2186750 + 135 WP_195717865.1 DUF3265 domain-containing protein -
EWA66_RS10605 2187226..2187516 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
EWA66_RS10610 2187506..2187754 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EWA66_RS10615 2187955..2188431 + 477 WP_025510224.1 GNAT family N-acetyltransferase -
EWA66_RS10620 2188416..2188538 + 123 WP_081947328.1 DUF3265 domain-containing protein -
EWA66_RS10625 2188667..2188804 + 138 WP_017048035.1 rubredoxin-like protein -
EWA66_RS10630 2188807..2189031 + 225 WP_017048036.1 DUF2188 domain-containing protein -
EWA66_RS10635 2189054..2189146 + 93 WP_193188328.1 DUF3265 domain-containing protein -
EWA66_RS10640 2189165..2189455 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
EWA66_RS10645 2189445..2189693 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EWA66_RS10650 2190202..2190327 + 126 WP_080003857.1 DUF3265 domain-containing protein -
EWA66_RS10655 2190540..2190791 + 252 WP_039444463.1 hypothetical protein -
EWA66_RS10660 2190815..2190964 - 150 WP_154199850.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1923154..2273696 350542
- inside Integron - - 2111244..2195416 84172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T118242 WP_005377002.1 NZ_CP035680:c2185861-2185571 [Vibrio navarrensis]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T118242 NZ_CP035680:c2185861-2185571 [Vibrio navarrensis]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCCACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT118242 WP_005377003.1 NZ_CP035680:c2186099-2185851 [Vibrio navarrensis]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT118242 NZ_CP035680:c2186099-2185851 [Vibrio navarrensis]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAATCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCCGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References