Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2119091..2119601 Replicon chromosome
Accession NZ_CP035680
Organism Vibrio navarrensis strain 08-2462

Toxin (Protein)


Gene name relB Uniprot ID A0A7Z7VK37
Locus tag EWA66_RS09925 Protein ID WP_000098715.1
Coordinates 2119338..2119601 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7Y3QZ95
Locus tag EWA66_RS09920 Protein ID WP_001223794.1
Coordinates 2119091..2119345 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWA66_RS09865 2114258..2114374 + 117 WP_081947313.1 DUF3265 domain-containing protein -
EWA66_RS09870 2114469..2114663 + 195 WP_039442075.1 hypothetical protein -
EWA66_RS09875 2114674..2114803 + 130 Protein_1849 DUF3265 domain-containing protein -
EWA66_RS09880 2115136..2115261 + 126 WP_081018692.1 DUF3265 domain-containing protein -
EWA66_RS09885 2115295..2115801 + 507 WP_039444366.1 GNAT family N-acetyltransferase -
EWA66_RS09890 2115811..2115939 + 129 WP_081947365.1 DUF3265 domain-containing protein -
EWA66_RS09895 2116348..2117882 + 1535 WP_154199842.1 IS3 family transposase -
EWA66_RS09905 2118315..2118374 + 60 WP_152593460.1 hypothetical protein -
EWA66_RS09910 2118422..2118883 + 462 WP_039445215.1 GNAT family N-acetyltransferase -
EWA66_RS09915 2118880..2118990 + 111 WP_081946553.1 DUF3265 domain-containing protein -
EWA66_RS09920 2119091..2119345 + 255 WP_001223794.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EWA66_RS09925 2119338..2119601 + 264 WP_000098715.1 Txe/YoeB family addiction module toxin Toxin
EWA66_RS09935 2119760..2120485 + 726 WP_039443314.1 DUF4241 domain-containing protein -
EWA66_RS09940 2120641..2121120 + 480 WP_039440271.1 GNAT family N-acetyltransferase -
EWA66_RS09945 2121102..2121227 + 126 WP_081946644.1 DUF3265 domain-containing protein -
EWA66_RS09950 2121261..2121869 + 609 WP_039439438.1 pyridoxamine 5'-phosphate oxidase family protein -
EWA66_RS09955 2121895..2121987 + 93 WP_195717864.1 DUF3265 domain-containing protein -
EWA66_RS09960 2122033..2122281 + 249 WP_154199844.1 hypothetical protein -
EWA66_RS09965 2122446..2122805 + 360 WP_152593357.1 hypothetical protein -
EWA66_RS20315 2122802..2122936 + 135 Protein_1866 DUF3265 domain-containing protein -
EWA66_RS09975 2122957..2123439 + 483 WP_039443561.1 hypothetical protein -
EWA66_RS09980 2123468..2123557 + 90 WP_072611516.1 DUF3265 domain-containing protein -
EWA66_RS09985 2123576..2124091 + 516 WP_039444429.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1923154..2273696 350542
- flank IS/Tn - - 2117067..2117882 815
- inside Integron - - 2111244..2195416 84172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10415.75 Da        Isoelectric Point: 7.9816

>T118239 WP_000098715.1 NZ_CP035680:2119338-2119601 [Vibrio navarrensis]
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITI
ISCRYHY

Download         Length: 264 bp

>T118239 NZ_CP035680:2119338-2119601 [Vibrio navarrensis]
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAAGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGATT
ATTTCGTGTCGCTACCATTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.64 Da        Isoelectric Point: 5.0481

>AT118239 WP_001223794.1 NZ_CP035680:2119091-2119345 [Vibrio navarrensis]
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE

Download         Length: 255 bp

>AT118239 NZ_CP035680:2119091-2119345 [Vibrio navarrensis]
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCCGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAACGCTGAACATCTAAACCGTTCCATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7VK37

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3QZ95

References