Detailed information of TA system TA118230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3572301..3573043
• Replicon: chromosome
• Accession: NZ_CP035676
• Organism: Salmonella bongori strain 04-0440

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: EWI73_RS16705
• Protein ID: WP_079772897.1
• Coordinates: 3572301..3572789 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: S5MPV7
• Locus tag: EWI73_RS16710
• Protein ID: WP_020844238.1
• Coordinates: 3572777..3573043 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWI73_RS16685 (3567976)	3567976..3569484	-	1509	WP_219344528.1	FAD-dependent oxidoreductase	-
EWI73_RS16690 (3569529)	3569529..3570017	+	489	WP_079772898.1	MarR family winged helix-turn-helix transcriptional regulator	-
EWI73_RS16695 (3570194)	3570194..3571261	+	1068	WP_219344529.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
EWI73_RS16700 (3571342)	3571342..3571731	-	390	WP_015702869.1	RidA family protein	-
EWI73_RS16705 (3572301)	3572301..3572789	-	489	WP_079772897.1	GNAT family N-acetyltransferase	Toxin
EWI73_RS16710 (3572777)	3572777..3573043	-	267	WP_020844238.1	DUF1778 domain-containing protein	Antitoxin
EWI73_RS16715 (3573163)	3573163..3575238	-	2076	WP_020844239.1	glycogen debranching protein GlgX	-
EWI73_RS16720 (3575281)	3575281..3577809	-	2529	WP_219344531.1	malto-oligosyltrehalose synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (32-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17779.59 Da
• Isoelectric Point: 9.5852

>T118230 WP_079772897.1 NZ_CP035676:c3572789-3572301 [Salmonella bongori]
VGKVTAPAPLSTLHNLAEFCCGESLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEAMGSLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Nucleotide

• Length: 489 bp

>T118230 NZ_CP035676:c3572789-3572301 [Salmonella bongori]
GTGGGAAAAGTAACCGCGCCTGCACCGTTATCCACGCTGCATAACCTGGCGGAATTCTGCTGCGGTGAAAGTCTGTTAGA
CGACTGGCTGCGGCAACGTGCGTTAAAAAACCAGGCGACTGGCGCATCCAGAACTTTTGTGGTGTGCAAAGCCGCCAGCC
ATCAGGTCGTTGGGTTTTATTCGCTGGCAACGGGCAGCGTTAATCACGCTGAAGCGATGGGCAGTTTGCGCCGCAATATG
CCCGATCCGATTCCGGTCATTATCCTGGCGCGTCTGGCTGTAGATGTGTCTTATCATGGAATCGGGCTGGGCGCGGATTT
ATTGCGCGATGCTATATTACGCGCGTATCGGGTGGCGGAAAATATCGGCGTTCGGGCGATGGTGGTGCAAGCGTTAACAG
AACAGGCTAAACGCTTCTATCTGCATCATGGTTTTCGGGAATCAGGTAAGCAAGAGAGAACGCTATTTCTTATCCTTCCG
GAAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9999.47 Da
• Isoelectric Point: 4.7961

>AT118230 WP_020844238.1 NZ_CP035676:c3573043-3572777 [Salmonella bongori]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Nucleotide

• Length: 267 bp

>AT118230 NZ_CP035676:c3573043-3572777 [Salmonella bongori]
ATGAAATCAGGCGTTCAACTCAATATTCGGGCCAAGGAGTCACAGCGGGCGTTGATCGATACGGCGGCCGAGATTCTGCA
TAAATCGCGAACCGACTTTATCCTTGAAATGGCTTGCCAGGCAGCCGAAAACGTTATTCTGGATCGCCGGGTATTTAACC
TTAACGACGATCAATACGCCGAGTTTGTTGAAATGCTTGATGCGCCTGTTGCTACAAATCCGGCGCTGGATAACTTACTG
GCGAGAAAACCACTGTGGGAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: S5MPV7