Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2597862..2598482 Replicon chromosome
Accession NZ_CP035676
Organism Salmonella bongori strain 04-0440

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag EWI73_RS12095 Protein ID WP_001280991.1
Coordinates 2597862..2598080 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag EWI73_RS12100 Protein ID WP_000344807.1
Coordinates 2598108..2598482 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWI73_RS12055 (2593101) 2593101..2593670 + 570 WP_219343986.1 YbaY family lipoprotein -
EWI73_RS12060 (2593703) 2593703..2594092 - 390 WP_000908589.1 MGMT family protein -
EWI73_RS12070 (2594331) 2594331..2595881 - 1551 WP_020842828.1 EAL domain-containing protein -
EWI73_RS12075 (2596086) 2596086..2596346 + 261 WP_000801419.1 type B 50S ribosomal protein L31 -
EWI73_RS12080 (2596352) 2596352..2596492 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
EWI73_RS12085 (2596544) 2596544..2597014 - 471 WP_079772190.1 YlaC family protein -
EWI73_RS12090 (2597132) 2597132..2597683 - 552 WP_219343990.1 maltose O-acetyltransferase -
EWI73_RS12095 (2597862) 2597862..2598080 - 219 WP_001280991.1 HHA domain-containing protein Toxin
EWI73_RS12100 (2598108) 2598108..2598482 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
EWI73_RS12105 (2598978) 2598978..2602127 - 3150 WP_001132513.1 efflux RND transporter permease AcrB -
EWI73_RS12110 (2602150) 2602150..2603343 - 1194 WP_020842830.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T118229 WP_001280991.1 NZ_CP035676:c2598080-2597862 [Salmonella bongori]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T118229 NZ_CP035676:c2598080-2597862 [Salmonella bongori]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAACTATCCGATAACGAGTTGGCTGTATTTTACTCAGCAGCAGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTTTACGACAAGATTCCTTCTTCTGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT118229 WP_000344807.1 NZ_CP035676:c2598482-2598108 [Salmonella bongori]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT118229 NZ_CP035676:c2598482-2598108 [Salmonella bongori]
ATGGACGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
GAACCTTGAAGAAAGCAACCATGGTTGGGTTAACGATCCGACCTCAGCAGTCAATCTTCAGCTCAATGAACTGATTGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCACAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTTCGCTGTTTTGTTAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References