Detailed information of TA system TA118228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1985625..1986268
• Replicon: chromosome
• Accession: NZ_CP035676
• Organism: Salmonella bongori strain 04-0440

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: EWI73_RS09310
• Protein ID: WP_219349635.1
• Coordinates: 1985625..1986041 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: B5F3H9
• Locus tag: EWI73_RS09315
• Protein ID: WP_001261294.1
• Coordinates: 1986038..1986268 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWI73_RS09290 (1980662)	1980662..1981795	+	1134	WP_219349633.1	amidohydrolase/deacetylase family metallohydrolase	-
EWI73_RS09295 (1981779)	1981779..1982897	+	1119	WP_038393597.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
EWI73_RS09300 (1982894)	1982894..1983634	+	741	WP_000779268.1	KDGP aldolase family protein	-
EWI73_RS09305 (1983651)	1983651..1985564	+	1914	WP_219349634.1	BglG family transcription antiterminator	-
EWI73_RS09310 (1985625)	1985625..1986041	-	417	WP_219349635.1	type II toxin-antitoxin system VapC family toxin	Toxin
EWI73_RS09315 (1986038)	1986038..1986268	-	231	WP_001261294.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
EWI73_RS09320 (1986435)	1986435..1986899	-	465	WP_219349636.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
EWI73_RS09325 (1987116)	1987116..1989254	-	2139	WP_219349637.1	anaerobic ribonucleoside-triphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15147.49 Da
• Isoelectric Point: 8.1381

>T118228 WP_219349635.1 NZ_CP035676:c1986041-1985625 [Salmonella bongori]
MSKTYILDTCICSFIMREQPEAVLKRLEQTVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Nucleotide

• Length: 417 bp

>T118228 NZ_CP035676:c1986041-1985625 [Salmonella bongori]
ATGAGTAAAACCTACATACTGGATACCTGCATCTGTTCTTTCATTATGCGTGAGCAGCCGGAAGCTGTGCTGAAACGCCT
TGAACAGACCGTGTTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGCCGTCTGGATGCCGTGTTGGCGTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCAATTGGATCAAACGATGCGGCTATCGC
CGGCCACGCTATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8878.90 Da
• Isoelectric Point: 4.6677

>AT118228 WP_001261294.1 NZ_CP035676:c1986268-1986038 [Salmonella bongori]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Nucleotide

• Length: 231 bp

>AT118228 NZ_CP035676:c1986268-1986038 [Salmonella bongori]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATTCTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCGGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Structures

Antitoxin

• AlphaFold DB: A0A3V4SIC2