Detailed information of TA system TA118227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1874839..1875617
• Replicon: chromosome
• Accession: NZ_CP035676
• Organism: Salmonella bongori strain 04-0440

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: EWI73_RS08735
• Protein ID: WP_079772477.1
• Coordinates: 1875129..1875617 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: EWI73_RS08730
• Protein ID: WP_079772475.1
• Coordinates: 1874839..1875132 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWI73_RS08720 (1871338)	1871338..1873374	-	2037	WP_257709985.1	type VI secretion system tip protein TssI/VgrG	-
EWI73_RS08725 (1874116)	1874116..1874442	-	327	Protein_1690	Arm DNA-binding domain-containing protein	-
EWI73_RS08730 (1874839)	1874839..1875132	+	294	WP_079772475.1	DUF1778 domain-containing protein	Antitoxin
EWI73_RS08735 (1875129)	1875129..1875617	+	489	WP_079772477.1	GNAT family N-acetyltransferase	Toxin
EWI73_RS08740 (1875713)	1875713..1876354	-	642	WP_219349599.1	hypothetical protein	-
EWI73_RS08745 (1876462)	1876462..1876746	-	285	WP_079772481.1	type VI secretion system PAAR protein	-
EWI73_RS08750 (1876937)	1876937..1877779	-	843	WP_219349600.1	hypothetical protein	-
EWI73_RS08755 (1877776)	1877776..1878606	-	831	WP_219349601.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	vgrG/tssI	1853200..1878606	25406

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-95)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17547.51 Da
• Isoelectric Point: 8.1467

>T118227 WP_079772477.1 NZ_CP035676:1875129-1875617 [Salmonella bongori]
MISAPEPLHTGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLGDLVG
SV

Nucleotide

• Length: 489 bp

>T118227 NZ_CP035676:1875129-1875617 [Salmonella bongori]
ATGATCTCCGCTCCAGAACCGCTTCATACCGGGCATATTCTTACCCCGTTCTGTTGCGGCGTGGATTCTATGGATAACTG
GCTAAAACAGCGGGCGATGAAGAACCAGCTTTCTGGCGCATCCCGCACGTTTGTCTGCTGTGACGATGCGAAGGTAATGG
CATACTACTCGCTGGCTTCAAGCGCTGTGACGACAAATACTGCGCCCGGTCGCTTCCGTCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGACGTCTGGCGGTGGATAAATCGCTGCATGGGAAGGGGGTTGGACGGGCGCTGGTGCGCGACGC
CGGGCTGCGGGTAATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCTCGGG
ATTTTTACCTGCGGGTGGGGTTTGAACCGTCGCCGATGGATCCGATGATGCTGATGGTGACGCTGGGAGATTTAGTGGGG
AGTGTTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10932.58 Da
• Isoelectric Point: 9.8590

>AT118227 WP_079772475.1 NZ_CP035676:1874839-1875132 [Salmonella bongori]
MPAANSMAMKRETLNLRIKPTERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT118227 NZ_CP035676:1874839-1875132 [Salmonella bongori]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGTGAAACCCTGAACTTGCGCATCAAACCCACCGAGCGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCGCCCAAT
GCCGCATTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA