Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 577026..577686 Replicon chromosome
Accession NZ_CP035676
Organism Salmonella bongori strain 04-0440

Toxin (Protein)


Gene name cptA Uniprot ID S5NC56
Locus tag EWI73_RS02690 Protein ID WP_000244759.1
Coordinates 577026..577439 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag EWI73_RS02695 Protein ID WP_000351186.1
Coordinates 577420..577686 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWI73_RS02670 (572968) 572968..574701 - 1734 WP_038392510.1 single-stranded-DNA-specific exonuclease RecJ -
EWI73_RS02675 (574707) 574707..575420 - 714 WP_079773249.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EWI73_RS02680 (575444) 575444..576340 - 897 WP_000806655.1 site-specific tyrosine recombinase XerD -
EWI73_RS02685 (576453) 576453..576974 + 522 WP_001055887.1 flavodoxin FldB -
EWI73_RS02690 (577026) 577026..577439 - 414 WP_000244759.1 protein YgfX Toxin
EWI73_RS02695 (577420) 577420..577686 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
EWI73_RS02700 (577933) 577933..578913 + 981 WP_219349302.1 tRNA-modifying protein YgfZ -
EWI73_RS02705 (578964) 578964..579623 - 660 WP_024143399.1 hemolysin III family protein -
EWI73_RS02710 (579787) 579787..580098 - 312 WP_015702996.1 N(4)-acetylcytidine aminohydrolase -
EWI73_RS02715 (580256) 580256..581689 + 1434 WP_219349303.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16190.13 Da        Isoelectric Point: 9.4274

>T118226 WP_000244759.1 NZ_CP035676:c577439-577026 [Salmonella bongori]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGE
DWVLLRPPWLLNSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRVMLQQPLSGQH

Download         Length: 414 bp

>T118226 NZ_CP035676:c577439-577026 [Salmonella bongori]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTAATTTTATTGATGCCCTGGCCGTTGAGTTATACCCCATTGTGGATGATGCTACTGTCGCTGGTGGTGTTTGACTGTG
TTCGTAGTCAGCGCCGGATTAATACCTGTCAGGGAGAGATCAAGCTGCTAATGGATGGGCGCTTACGCTGGCAGGGGGAA
GACTGGGTGCTCCTGCGCCCGCCCTGGTTACTGAACAGCGGGATGGTGTTGCGTTTACGCGCCGAGTCCGGACGTCATCA
GCATTTATGGCTGGCAGCGGATAGCATGGAAGAGGCGGAATGGCGTGAGTTACGCCGTGTCATGTTGCAACAACCACTAT
CGGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT118226 WP_000351186.1 NZ_CP035676:c577686-577420 [Salmonella bongori]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT118226 NZ_CP035676:c577686-577420 [Salmonella bongori]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGCGACGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAGCTGGAACAAATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NC56

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References