Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 768028..768505 Replicon chromosome
Accession NZ_CP035671
Organism Staphylococcus aureus strain VB31683

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EWG56_RS03940 Protein ID WP_000052076.1
Coordinates 768317..768505 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EWG56_RS03935 Protein ID WP_001059690.1
Coordinates 768028..768288 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWG56_RS03900 763427..764143 - 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -
EWG56_RS03905 764291..764713 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
EWG56_RS03910 765112..765594 + 483 WP_123186506.1 GNAT family N-acetyltransferase -
EWG56_RS03915 765756..766373 + 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
EWG56_RS03920 766446..767027 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
EWG56_RS03925 767252..767488 + 237 WP_000368687.1 hypothetical protein -
EWG56_RS03930 767485..767688 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EWG56_RS03935 768028..768288 + 261 WP_001059690.1 hypothetical protein Antitoxin
EWG56_RS03940 768317..768505 + 189 WP_000052076.1 hypothetical protein Toxin
EWG56_RS03945 768693..769262 + 570 WP_001106646.1 hypothetical protein -
EWG56_RS03950 769350..769634 + 285 WP_001004395.1 hypothetical protein -
EWG56_RS03955 769696..769914 + 219 WP_000005876.1 hypothetical protein -
EWG56_RS03960 770410..770610 - 201 WP_001059082.1 cold-shock protein -
EWG56_RS03965 770967..771653 - 687 WP_001670297.1 thermonuclease family protein -
EWG56_RS03970 771994..772515 - 522 WP_000824488.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T118209 WP_000052076.1 NZ_CP035671:768317-768505 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T118209 NZ_CP035671:768317-768505 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT118209 WP_001059690.1 NZ_CP035671:768028-768288 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT118209 NZ_CP035671:768028-768288 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References