Detailed information of TA system TA118207

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 3738390..3738912
• Replicon: chromosome
• Accession: NZ_CP035668
• Organism: Edwardsiella piscicida strain MS-18-199

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EVK84_RS17230
• Protein ID: WP_129986137.1
• Coordinates: 3738631..3738912 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A411H7D8
• Locus tag: EVK84_RS17225
• Protein ID: WP_069578569.1
• Coordinates: 3738390..3738641 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EVK84_RS17195	3733673..3734335	-	663	WP_109579934.1	hypothetical protein	-
EVK84_RS17200	3734335..3734916	-	582	WP_129986131.1	hypothetical protein	-
EVK84_RS17205	3734916..3735359	-	444	WP_080783445.1	hypothetical protein	-
EVK84_RS17210	3735401..3735796	-	396	WP_080783446.1	hypothetical protein	-
EVK84_RS17215	3735855..3737093	-	1239	WP_129986133.1	N4-gp56 family major capsid protein	-
EVK84_RS17220	3737111..3738112	-	1002	WP_129986135.1	hypothetical protein	-
EVK84_RS17225	3738390..3738641	+	252	WP_069578569.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EVK84_RS17230	3738631..3738912	+	282	WP_129986137.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EVK84_RS17235	3738985..3741099	-	2115	WP_129986139.1	portal protein	-
EVK84_RS17240	3741096..3742757	-	1662	WP_165362063.1	terminase	-
EVK84_RS17245	3742750..3743526	-	777	WP_073382315.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3712864..3820549	107685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10690.58 Da
• Isoelectric Point: 10.6993

>T118207 WP_129986137.1 NZ_CP035668:3738631-3738912 [Edwardsiella piscicida]
MTYKLSVEKRALKEWKKLAPPIQSQLKKKLIERLENPHIPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNDVYLAADGR

Nucleotide

• Length: 282 bp

>T118207 NZ_CP035668:3738631-3738912 [Edwardsiella piscicida]
ATGACCTATAAACTGAGCGTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCCATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTAGAAAATCCACATATCCCGGCCGCCCGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGATCTTCCGGTTATCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGAGCCGATAACGACGTGTACCTAGCGGCAGACGGTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9154.26 Da
• Isoelectric Point: 3.8074

>AT118207 WP_069578569.1 NZ_CP035668:3738390-3738641 [Edwardsiella piscicida]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAENAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT118207 NZ_CP035668:3738390-3738641 [Edwardsiella piscicida]
ATGGCATACCAAATTCTCACTACAACAGCCGCCAGTATTACCGATCTAAAACGCAATCCGATGGGTACCATTGCTGAGGG
TGACGGCAATGCCGTCGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAGCTCTATGCTTACTACC
TGGAGCTGGCTGAAAATGCTGCTCTTAATCGTATCGCCGATGAGCGTCTAGAGGACGCTGAATTCGTCAGCGTAAATATC
GATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A411H7D8