118198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 2446433..2447165 Replicon chromosome
Accession NZ_CP035668
Organism Edwardsiella piscicida strain MS-18-199

Toxin (Protein)


Gene name ypjF Uniprot ID A0A411H496
Locus tag EVK84_RS11140 Protein ID WP_015683453.1
Coordinates 2446433..2446762 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A411H489
Locus tag EVK84_RS11145 Protein ID WP_015683452.1
Coordinates 2446800..2447165 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EVK84_RS11115 2442814..2444097 + 1284 WP_012849580.1 serine dehydratase subunit alpha family protein -
EVK84_RS11120 2444161..2444898 + 738 WP_172454870.1 AzlC family ABC transporter permease -
EVK84_RS11125 2444891..2445217 + 327 WP_129985861.1 AzlD domain-containing protein -
EVK84_RS11130 2445254..2445640 + 387 WP_012849577.1 RidA family protein -
EVK84_RS11135 2445757..2446053 - 297 WP_012849576.1 hypothetical protein -
EVK84_RS11140 2446433..2446762 - 330 WP_015683453.1 TA system toxin CbtA family protein Toxin
EVK84_RS11145 2446800..2447165 - 366 WP_015683452.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EVK84_RS11150 2447191..2447412 - 222 WP_015683451.1 DUF987 domain-containing protein -
EVK84_RS11155 2447409..2447951 - 543 WP_041692659.1 DNA repair protein RadC -
EVK84_RS11160 2447964..2448407 - 444 WP_047414857.1 antirestriction protein -
EVK84_RS11165 2448438..2449259 - 822 WP_041692658.1 DUF945 domain-containing protein -
EVK84_RS11170 2449358..2449588 - 231 WP_015683448.1 DUF905 domain-containing protein -
EVK84_RS11175 2449660..2450109 - 450 WP_015683447.1 hypothetical protein -
EVK84_RS11180 2450106..2450559 - 454 Protein_2117 hypothetical protein -
EVK84_RS11185 2450594..2451214 - 621 WP_041692657.1 hypothetical protein -
EVK84_RS11190 2451211..2451924 - 714 WP_041692656.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12617.29 Da        Isoelectric Point: 9.5061

>T118198 WP_015683453.1 NZ_CP035668:c2446762-2446433 [Edwardsiella piscicida]
MQTLSSHPTRSTQPYLSPVETWQRLLTHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYELIRIDRKGF
SWQQQTPYISVVDILRARRNTGLLKTNVK

Download         Length: 330 bp

>T118198 NZ_CP035668:c2446762-2446433 [Edwardsiella piscicida]
ATGCAAACCTTATCATCACACCCGACACGGTCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTATTCTCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGAAACCACCATACGAGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGAGCTTATCCGTATCGATCGGAAGGGATTT
TCGTGGCAACAACAGACTCCGTATATTTCCGTAGTGGATATTCTACGAGCAAGACGCAATACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13477.21 Da        Isoelectric Point: 5.8743

>AT118198 WP_015683452.1 NZ_CP035668:c2447165-2446800 [Edwardsiella piscicida]
MNNHSESGTKPENLTCQQWGLKRTITPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLTSGE
LSPLHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPDQPEPH

Download         Length: 366 bp

>AT118198 NZ_CP035668:c2447165-2446800 [Edwardsiella piscicida]
ATGAACAATCACTCTGAATCCGGTACCAAACCGGAGAATCTTACCTGCCAGCAGTGGGGACTAAAGCGCACGATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGGCAACCGGGTGCATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GCGACAACGATGCATTGCGCCTCGACCAGGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTCACCAGCGGAGAA
CTCTCTCCCTTGCATCAGCACTGCGTCACGCTATATCACAATGGACTGACTTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATCGCTATTTATCCCGACCAGCCTGAACCCCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H496

Antitoxin

Source ID Structure
AlphaFold DB A0A411H489

References