Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2241669..2242332 Replicon chromosome
Accession NZ_CP035668
Organism Edwardsiella piscicida strain MS-18-199

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag EVK84_RS10225 Protein ID WP_034167931.1
Coordinates 2241916..2242332 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag EVK84_RS10220 Protein ID WP_012849755.1
Coordinates 2241669..2241935 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EVK84_RS10200 2237152..2237802 - 651 WP_015462279.1 hemolysin III family protein -
EVK84_RS10205 2238419..2239291 + 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
EVK84_RS10210 2239450..2240274 + 825 WP_109745894.1 shikimate 5-dehydrogenase -
EVK84_RS10215 2240317..2241315 - 999 WP_012849756.1 tRNA-modifying protein YgfZ -
EVK84_RS10220 2241669..2241935 + 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
EVK84_RS10225 2241916..2242332 + 417 WP_034167931.1 protein YgfX Toxin
EVK84_RS10230 2242357..2242869 - 513 WP_012849753.1 flavodoxin FldB -
EVK84_RS10235 2243020..2243919 + 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
EVK84_RS10240 2243947..2244663 + 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EVK84_RS10245 2244668..2246401 + 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T118197 WP_034167931.1 NZ_CP035668:2241916-2242332 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T118197 NZ_CP035668:2241916-2242332 [Edwardsiella piscicida]
GTGGTCCTTTGGCGCTGTAATGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCGCGCTGGTACT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGCCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGACGCCCTTGGGTTAGCGATCTGGGGGCGCTGCTGATCCTGCAGAGTACCCATGGTGCGCCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATGCGG
GCGACGATCGCGCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT118197 WP_012849755.1 NZ_CP035668:2241669-2241935 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT118197 NZ_CP035668:2241669-2241935 [Edwardsiella piscicida]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCCATCATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGTGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGATGACGCCGATCTGGCCCGCATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References