118194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 499263..499855 Replicon chromosome
Accession NZ_CP035668
Organism Edwardsiella piscicida strain MS-18-199

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag EVK84_RS02325 Protein ID WP_012847872.1
Coordinates 499652..499855 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag EVK84_RS02320 Protein ID WP_015461125.1
Coordinates 499263..499631 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EVK84_RS02310 494514..495698 + 1185 WP_034168424.1 efflux RND transporter periplasmic adaptor subunit -
EVK84_RS02315 495742..498894 + 3153 WP_012847874.1 multidrug efflux RND transporter permease subunit -
EVK84_RS02320 499263..499631 + 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
EVK84_RS02325 499652..499855 + 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
EVK84_RS02340 500337..500693 + 357 WP_041692719.1 MGMT family protein -
EVK84_RS02345 500802..501668 + 867 WP_012847869.1 acyl-CoA thioesterase II -
EVK84_RS02350 501703..502983 - 1281 WP_041692495.1 ammonium transporter AmtB -
EVK84_RS02355 503005..503343 - 339 WP_012847867.1 P-II family nitrogen regulator -
EVK84_RS02360 503648..504109 - 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T118194 WP_012847872.1 NZ_CP035668:499652-499855 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T118194 NZ_CP035668:499652-499855 [Edwardsiella piscicida]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT118194 WP_015461125.1 NZ_CP035668:499263-499631 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT118194 NZ_CP035668:499263-499631 [Edwardsiella piscicida]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGCTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References