118178

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1674155..1674664 Replicon chromosome
Accession NZ_CP035643
Organism Staphylococcus epidermidis strain E73

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag EVU95_RS08085 Protein ID WP_001829980.1
Coordinates 1674155..1674364 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag EVU95_RS08090 Protein ID WP_001829893.1
Coordinates 1674371..1674664 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EVU95_RS08065 1669733..1671088 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
EVU95_RS08070 1671100..1672173 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
EVU95_RS08075 1672564..1673775 + 1212 WP_002486299.1 rod shape-determining protein RodA -
EVU95_RS08080 1673874..1674011 - 138 WP_001829949.1 hypothetical protein -
EVU95_RS08085 1674155..1674364 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
EVU95_RS08090 1674371..1674664 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
EVU95_RS08095 1674838..1676322 + 1485 WP_002457116.1 cardiolipin synthase -
EVU95_RS08100 1676504..1677157 + 654 WP_001829983.1 HD domain-containing protein -
EVU95_RS08105 1677263..1678135 - 873 WP_002470121.1 membrane protein insertase YidC -
EVU95_RS08110 1678224..1678862 - 639 WP_002505076.1 thiamine phosphate synthase -
EVU95_RS08115 1678868..1679656 - 789 WP_002469583.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T118178 WP_001829980.1 NZ_CP035643:c1674364-1674155 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T118178 NZ_CP035643:c1674364-1674155 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT118178 WP_001829893.1 NZ_CP035643:c1674664-1674371 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT118178 NZ_CP035643:c1674664-1674371 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References