Detailed information of TA system TA118176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1499129..1499931
• Replicon: chromosome
• Accession: NZ_CP035643
• Organism: Staphylococcus epidermidis strain E73

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q5HN83
• Locus tag: EVU95_RS07075
• Protein ID: WP_002468490.1
• Coordinates: 1499129..1499308 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: EVU95_RS07080
• Protein ID: WP_002486232.1
• Coordinates: 1499332..1499931 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EVU95_RS07055	1494522..1495655	-	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-
EVU95_RS07060	1495814..1496638	+	825	WP_001829804.1	RluA family pseudouridine synthase	-
EVU95_RS07065	1496999..1498384	-	1386	WP_001829862.1	class II fumarate hydratase	-
EVU95_RS07070	1498569..1498973	-	405	WP_002485605.1	hypothetical protein	-
EVU95_RS07075	1499129..1499308	-	180	WP_002468490.1	hypothetical protein	Toxin
EVU95_RS07080	1499332..1499931	-	600	WP_002486232.1	glucosamine-6-phosphate isomerase	Antitoxin
EVU95_RS07085	1500089..1500559	-	471	WP_001829836.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
EVU95_RS07090	1500556..1501686	-	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
EVU95_RS07095	1502547..1503269	-	723	WP_001829838.1	amino acid ABC transporter ATP-binding protein	-
EVU95_RS07100	1503262..1504719	-	1458	WP_002440300.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6963.56 Da
• Isoelectric Point: 4.3016

>T118176 WP_002468490.1 NZ_CP035643:c1499308-1499129 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Nucleotide

• Length: 180 bp

>T118176 NZ_CP035643:c1499308-1499129 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22695.55 Da
• Isoelectric Point: 4.8641

>AT118176 WP_002486232.1 NZ_CP035643:c1499931-1499332 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT118176 NZ_CP035643:c1499931-1499332 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAACCTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Structures

Toxin

• AlphaFold DB: A0A2G7HY44