Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3424486..3425143 Replicon chromosome
Accession NZ_CP035633
Organism Enterobacter cloacae strain EN3600

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag EVV94_RS17250 Protein ID WP_021242050.1
Coordinates 3424486..3424896 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag EVV94_RS17255 Protein ID WP_010435322.1
Coordinates 3424877..3425143 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EVV94_RS17230 3420479..3422212 - 1734 WP_039262981.1 single-stranded-DNA-specific exonuclease RecJ -
EVV94_RS17235 3422218..3422931 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EVV94_RS17240 3422960..3423856 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
EVV94_RS17245 3423958..3424479 + 522 WP_064673272.1 flavodoxin FldB -
EVV94_RS17250 3424486..3424896 - 411 WP_021242050.1 protein YgfX Toxin
EVV94_RS17255 3424877..3425143 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
EVV94_RS17260 3425438..3426418 + 981 WP_029739202.1 tRNA-modifying protein YgfZ -
EVV94_RS17265 3426493..3427152 - 660 WP_033146591.1 hemolysin III family protein -
EVV94_RS17270 3427318..3427629 - 312 WP_094935379.1 N(4)-acetylcytidine aminohydrolase -
EVV94_RS17275 3427681..3428412 + 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
EVV94_RS17280 3428529..3429962 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T118170 WP_021242050.1 NZ_CP035633:c3424896-3424486 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T118170 NZ_CP035633:c3424896-3424486 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTCGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT118170 WP_010435322.1 NZ_CP035633:c3425143-3424877 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT118170 NZ_CP035633:c3425143-3424877 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References