Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 85608..86209 | Replicon | plasmid pYU07-18_89 |
| Accession | NZ_CP035549 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain YU07-18 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A731GHK2 |
| Locus tag | D6D39_RS25045 | Protein ID | WP_001216038.1 |
| Coordinates | 85829..86209 (+) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | D6D39_RS25040 | Protein ID | WP_001190712.1 |
| Coordinates | 85608..85829 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D6D39_RS24985 | 80895..81194 | + | 300 | WP_046891370.1 | hypothetical protein | - |
| D6D39_RS24990 | 81181..81828 | + | 648 | WP_000034256.1 | ead/Ea22-like family protein | - |
| D6D39_RS24995 | 81815..82006 | + | 192 | WP_001557730.1 | hypothetical protein | - |
| D6D39_RS25000 | 82008..82223 | + | 216 | WP_001557731.1 | hypothetical protein | - |
| D6D39_RS25005 | 82225..82680 | + | 456 | WP_001142594.1 | DUF4014 family protein | - |
| D6D39_RS25010 | 82691..83407 | + | 717 | Protein_95 | DUF551 domain-containing protein | - |
| D6D39_RS25015 | 83753..84027 | + | 275 | Protein_96 | antitoxin PHD | - |
| D6D39_RS25020 | 84012..84221 | - | 210 | WP_001344848.1 | hypothetical protein | - |
| D6D39_RS25025 | 84395..84541 | + | 147 | WP_001443773.1 | hypothetical protein | - |
| D6D39_RS25030 | 84553..84942 | + | 390 | WP_022630896.1 | DNA repair protein | - |
| D6D39_RS25035 | 85077..85499 | + | 423 | WP_000098854.1 | hypothetical protein | - |
| D6D39_RS25040 | 85608..85829 | + | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| D6D39_RS25045 | 85829..86209 | + | 381 | WP_001216038.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| D6D39_RS25050 | 86214..86411 | + | 198 | WP_000113017.1 | hypothetical protein | - |
| D6D39_RS25055 | 86444..87220 | - | 777 | WP_022630895.1 | hypothetical protein | - |
| D6D39_RS25060 | 87227..87667 | - | 441 | WP_001557736.1 | DUF2829 domain-containing protein | - |
| D6D39_RS25065 | 87682..88176 | - | 495 | WP_001557737.1 | dUTP diphosphatase | - |
| D6D39_RS25070 | 88173..88649 | - | 477 | WP_001557738.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..88898 | 88898 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 16296.13 Da Isoelectric Point: 12.9004
>T118154 WP_001216038.1 NZ_CP035549:85829-86209 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Download Length: 381 bp
>T118154 NZ_CP035549:85829-86209 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin
Download Length: 74 a.a. Molecular weight: 9502.90 Da Isoelectric Point: 12.6633
>AT118154 WP_001190712.1 NZ_CP035549:85608-85829 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Download Length: 222 bp
>AT118154 NZ_CP035549:85608-85829 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A731GHK2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |