Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2108620..2109091 Replicon chromosome
Accession NZ_CP035545
Organism Escherichia coli strain FSIS11705876

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag EB814_RS10470 Protein ID WP_001303511.1
Coordinates 2108813..2109091 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag EB814_RS10465 Protein ID WP_001302048.1
Coordinates 2108620..2108811 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB814_RS10425 2103827..2104411 - 585 WP_000206793.1 DUF551 domain-containing protein -
EB814_RS10430 2104468..2104863 - 396 WP_001118159.1 DUF977 family protein -
EB814_RS10435 2104879..2105648 - 770 Protein_2041 DUF1627 domain-containing protein -
EB814_RS10440 2105674..2106414 - 741 WP_000788938.1 ATP-binding protein -
EB814_RS10445 2106421..2107383 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
EB814_RS10450 2107406..2107831 - 426 WP_000693943.1 Rha family transcriptional regulator -
EB814_RS10455 2107828..2108130 - 303 WP_000172738.1 transcriptional regulator -
EB814_RS10460 2108228..2108599 + 372 WP_001169686.1 hypothetical protein -
EB814_RS10465 2108620..2108811 + 192 WP_001302048.1 hypothetical protein Antitoxin
EB814_RS10470 2108813..2109091 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EB814_RS10475 2109444..2109743 + 300 WP_001240334.1 hypothetical protein -
EB814_RS10480 2109815..2110033 + 219 WP_001171930.1 hypothetical protein -
EB814_RS10490 2110602..2110790 + 189 WP_000449192.1 cell division inhibition protein DicB -
EB814_RS10495 2110787..2110978 + 192 WP_001090200.1 DUF1482 family protein -
EB814_RS10500 2111071..2112156 + 1086 Protein_2053 exonuclease -
EB814_RS10505 2112207..2113419 + 1213 Protein_2054 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 2027699..2117564 89865


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T118126 WP_001303511.1 NZ_CP035545:2108813-2109091 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T118126 NZ_CP035545:2108813-2109091 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT118126 WP_001302048.1 NZ_CP035545:2108620-2108811 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT118126 NZ_CP035545:2108620-2108811 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References