Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1398025..1398820 Replicon chromosome
Accession NZ_CP035545
Organism Escherichia coli strain FSIS11705876

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag EB814_RS06555 Protein ID WP_000854914.1
Coordinates 1398446..1398820 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag EB814_RS06550 Protein ID WP_001280954.1
Coordinates 1398025..1398399 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB814_RS06520 1393380..1394285 + 906 WP_000203541.1 chemotaxis protein -
EB814_RS06525 1394282..1395352 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
EB814_RS06530 1395692..1396510 + 819 WP_001234682.1 DUF945 domain-containing protein -
EB814_RS06535 1396601..1397086 + 486 WP_000214398.1 antirestriction protein -
EB814_RS06540 1397102..1397578 + 477 WP_001186738.1 RadC family protein -
EB814_RS06545 1397641..1397862 + 222 WP_001220314.1 DUF987 domain-containing protein -
EB814_RS06550 1398025..1398399 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EB814_RS06555 1398446..1398820 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
EB814_RS06560 1398817..1399308 + 492 WP_000976853.1 hypothetical protein -
EB814_RS06565 1399320..1399517 + 198 WP_000839282.1 DUF957 domain-containing protein -
EB814_RS06570 1399602..1400444 + 843 WP_001280481.1 DUF4942 domain-containing protein -
EB814_RS06580 1400915..1401853 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
EB814_RS06585 1401908..1402645 + 738 WP_000283664.1 zinc-binding phosphatase -
EB814_RS06590 1402669..1403223 + 555 WP_001001917.1 molecular chaperone YcdY -
EB814_RS06595 1403325..1403816 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T118120 WP_000854914.1 NZ_CP035545:1398446-1398820 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T118120 NZ_CP035545:1398446-1398820 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT118120 WP_001280954.1 NZ_CP035545:1398025-1398399 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT118120 NZ_CP035545:1398025-1398399 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References