Detailed information of TA system TA118117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1171104..1171582
• Replicon: chromosome
• Accession: NZ_CP035545
• Organism: Escherichia coli strain FSIS11705876

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: EB814_RS05365
• Protein ID: WP_001303876.1
• Coordinates: 1171104..1171391 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: EB814_RS05370
• Protein ID: WP_000536233.1
• Coordinates: 1171391..1171582 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB814_RS05335	1166253..1168724	-	2472	WP_000034474.1	exonuclease	-
EB814_RS05340	1168818..1169009	-	192	WP_001098307.1	DUF1482 family protein	-
EB814_RS05345	1169006..1169194	-	189	WP_000413705.1	cell division inhibition protein DicB	-
EB814_RS05350	1169768..1169953	+	186	WP_001133046.1	hypothetical protein	-
EB814_RS05355	1170140..1170529	-	390	WP_000394511.1	hypothetical protein	-
EB814_RS05360	1170671..1170826	-	156	WP_000379575.1	DUF1391 family protein	-
EB814_RS05365	1171104..1171391	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EB814_RS05370	1171391..1171582	-	192	WP_000536233.1	hypothetical protein	Antitoxin
EB814_RS05375	1171610..1172011	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
EB814_RS05380	1172120..1172392	+	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
EB814_RS05385	1172376..1172801	+	426	WP_000693855.1	Rha family transcriptional regulator	-
EB814_RS05390	1173008..1173463	-	456	WP_000273724.1	hypothetical protein	-
EB814_RS05395	1173542..1174633	+	1092	WP_001205823.1	hypothetical protein	-
EB814_RS05400	1174640..1175386	+	747	WP_000788745.1	ATP-binding protein	-
EB814_RS05405	1175408..1176094	+	687	WP_153983941.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1157604..1177358	19754

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T118117 WP_001303876.1 NZ_CP035545:c1171391-1171104 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T118117 NZ_CP035545:c1171391-1171104 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT118117 WP_000536233.1 NZ_CP035545:c1171582-1171391 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT118117 NZ_CP035545:c1171582-1171391 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA