Detailed information of TA system TA118111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2052452..2052920
• Replicon: chromosome
• Accession: NZ_CP035541
• Organism: Staphylococcus haemolyticus strain PK-01

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q4L4Q4
• Locus tag: EU512_RS10275
• Protein ID: WP_011276326.1
• Coordinates: 2052732..2052920 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: Q4L4Q5
• Locus tag: EU512_RS10270
• Protein ID: WP_011276325.1
• Coordinates: 2052452..2052709 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EU512_RS10235	2047628..2048353	-	726	WP_037558439.1	type I 3-dehydroquinate dehydratase	-
EU512_RS10240	2048516..2048938	+	423	WP_016931015.1	organic hydroperoxide resistance protein	-
EU512_RS10245	2049201..2049692	+	492	WP_011276321.1	GNAT family N-acetyltransferase	-
EU512_RS10250	2049824..2050441	+	618	WP_011276322.1	LysE/ArgO family amino acid transporter	-
EU512_RS10255	2050628..2051236	-	609	WP_011276323.1	phosphoglycerate mutase family protein	-
EU512_RS10260	2051464..2051706	+	243	WP_011276324.1	hypothetical protein	-
EU512_RS10265	2051698..2051901	-	204	WP_033079647.1	sterile alpha motif-like domain-containing protein	-
EU512_RS10270	2052452..2052709	+	258	WP_011276325.1	hypothetical protein	Antitoxin
EU512_RS10275	2052732..2052920	+	189	WP_011276326.1	hypothetical protein	Toxin
EU512_RS10280	2053038..2053619	+	582	WP_033079646.1	orthopoxovirus protein, PF05708 family	-
EU512_RS10285	2053667..2053903	-	237	WP_016931008.1	hypothetical protein	-
EU512_RS10290	2054073..2054819	+	747	WP_033079645.1	membrane lipoprotein lipid attachment site-containing protein	-
EU512_RS10295	2054888..2055496	-	609	WP_033079644.1	GNAT family N-acetyltransferase	-
EU512_RS10300	2055633..2056379	+	747	WP_033079643.1	poly-gamma-glutamate hydrolase family protein	-
EU512_RS10305	2056455..2056742	+	288	WP_033079642.1	hypothetical protein	-
EU512_RS10310	2056986..2057210	+	225	WP_033079641.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	fusB	-	2051464..2081832	30368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-109)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7110.80 Da
• Isoelectric Point: 9.6269

>T118111 WP_011276326.1 NZ_CP035541:2052732-2052920 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Nucleotide

• Length: 189 bp

>T118111 NZ_CP035541:2052732-2052920 [Staphylococcus haemolyticus]
ATGAGTTTGCATTTAACTATATTGTTATGGCTTGGTATCATTTTTGTAATAGCAGCCTCAATTATATTGGGCTTATTACT
TAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGTTTTACCGTAATATTTTATATTTTTGGATTTGCTTTACTCA
TCTACGTATTCATATTTGGTATATTATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9914.97 Da
• Isoelectric Point: 4.0625

>AT118111 WP_011276325.1 NZ_CP035541:2052452-2052709 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Nucleotide

• Length: 258 bp

>AT118111 NZ_CP035541:2052452-2052709 [Staphylococcus haemolyticus]
ATGAATAATAATAAAATTTTTTGGATAAATATTTTTATGACGCTATTATTTTTGGGTTTCAATATCATTGTCACTTACAA
TGCAGACTTAGATGATTTCTTCTGGCTAATTCCAGGACTGACAATTAGTGGTATCACAATTGTACTAAGCTTAAGTACTG
CGCTCATTTGCAAGAACCTGGTTAGCGAAGTTATTTTTCTAATCAATATTGTTATGCTTTTATACTACATTTATCCTATG
GTATATACATTCTTTTAA

Structures

Toxin

• AlphaFold DB: A0A2A1KAB5

Antitoxin

• AlphaFold DB: A0A2A1KAX9