Detailed information of TA system TA118110

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1075273..1076044
• Replicon: chromosome
• Accession: NZ_CP035541
• Organism: Staphylococcus haemolyticus strain PK-01

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: EU512_RS05415
• Protein ID: WP_011275410.1
• Coordinates: 1075895..1076044 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: EU512_RS05410
• Protein ID: WP_011275409.1
• Coordinates: 1075273..1075872 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EU512_RS05390	1071156..1072610	+	1455	WP_011275405.1	ABC transporter substrate-binding protein/permease	-
EU512_RS05395	1072603..1073325	+	723	WP_016931345.1	amino acid ABC transporter ATP-binding protein	-
EU512_RS05400	1073503..1074630	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
EU512_RS05405	1074631..1075101	+	471	WP_016931343.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
EU512_RS05410	1075273..1075872	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
EU512_RS05415	1075895..1076044	+	150	WP_011275410.1	hypothetical protein	Toxin
EU512_RS05420	1076255..1076650	+	396	WP_011275411.1	hypothetical protein	-
EU512_RS05425	1076857..1078242	+	1386	WP_037571293.1	class II fumarate hydratase	-
EU512_RS05430	1078308..1079132	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
EU512_RS05435	1079320..1080429	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T118110 WP_011275410.1 NZ_CP035541:1075895-1076044 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T118110 NZ_CP035541:1075895-1076044 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT118110 WP_011275409.1 NZ_CP035541:1075273-1075872 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT118110 NZ_CP035541:1075273-1075872 [Staphylococcus haemolyticus]
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAATAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTTTAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCTTACTATGAAGCATTAGGTGTA
CCTGCTAGTCAAATTTATCCAATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCATCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAGGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2