Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 950837..951369 Replicon chromosome
Accession NZ_CP035541
Organism Staphylococcus haemolyticus strain PK-01

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag EU512_RS04665 Protein ID WP_011275272.1
Coordinates 951004..951369 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag EU512_RS04660 Protein ID WP_011275271.1
Coordinates 950837..951007 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EU512_RS04635 946623..947102 + 480 WP_011275266.1 PH domain-containing protein -
EU512_RS04640 947095..948618 + 1524 WP_016931363.1 PH domain-containing protein -
EU512_RS04645 948611..949138 + 528 WP_033080076.1 PH domain-containing protein -
EU512_RS04650 949148..949507 + 360 WP_011275269.1 holo-ACP synthase -
EU512_RS04655 949603..950751 + 1149 WP_016931365.1 alanine racemase -
EU512_RS04660 950837..951007 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EU512_RS04665 951004..951369 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EU512_RS04670 951677..952678 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
EU512_RS04675 952777..953103 + 327 WP_011275274.1 anti-sigma factor antagonist -
EU512_RS04680 953105..953584 + 480 WP_011275275.1 anti-sigma B factor RsbW -
EU512_RS04685 953559..954329 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T118109 WP_011275272.1 NZ_CP035541:951004-951369 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T118109 NZ_CP035541:951004-951369 [Staphylococcus haemolyticus]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTGTCACCAGTACAGGGCTCAGAACAAGGGGGAGTCAGACCTGTAGT
TATCATTCAAAACGATACTGGTAACAAATATAGTCCTACCGTAATCGTTGCTGCGATTACGGGAAGGATTAATAAAGCGA
AAATACCCACACATGTTGAAATCGAGAAAAAGAAATACAGACTTGATAAAGATTCAGTTATTCTACTCGAGCAAATTAGA
ACATTAGATAAAAAACGACTAAAAGAAAAATTAACATATCTATCTGATGAGAAAATGCAAGAAGTGGATGAAGCGTTAGA
CATTAGTCTAGGATTGCATGATGAAGTTAAAACGCAAAACACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT118109 WP_011275271.1 NZ_CP035541:950837-951007 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT118109 NZ_CP035541:950837-951007 [Staphylococcus haemolyticus]
ATGCTTACTTTCAATCAAAATAGAAGTCACAGTCTTGAACAATCTTTAAAAGAAGGCTATGCACAAATGGCCGAATTAAA
TCTCTCCCTAGCGACAGAAGCTTTTCCTCTAGAATGCGAAGCTTGTGATTGCAACGAAACGTACCTTATTTCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References