Detailed information of TA system TA118108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 939315..939826
• Replicon: chromosome
• Accession: NZ_CP035541
• Organism: Staphylococcus haemolyticus strain PK-01

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: EU512_RS04600
• Protein ID: WP_011275259.1
• Coordinates: 939620..939826 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: EU512_RS04595
• Protein ID: WP_011275258.1
• Coordinates: 939315..939608 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EU512_RS04570	934750..935388	+	639	WP_011275254.1	thiamine phosphate synthase	-
EU512_RS04575	935477..936352	+	876	WP_011275255.1	membrane protein insertase YidC	-
EU512_RS04580	936546..936854	+	309	Protein_914	transposase	-
EU512_RS04585	936903..937544	-	642	WP_016931420.1	HD domain-containing protein	-
EU512_RS04590	937644..939128	-	1485	WP_011275257.1	cardiolipin synthase	-
EU512_RS04595	939315..939608	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
EU512_RS04600	939620..939826	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
EU512_RS04605	939934..940071	+	138	WP_011275260.1	hypothetical protein	-
EU512_RS04610	940390..940659	+	270	Protein_920	IS5/IS1182 family transposase	-
EU512_RS04615	940617..941816	-	1200	WP_011275262.1	rod shape-determining protein RodA	-
EU512_RS04620	942234..943304	+	1071	WP_011275263.1	D-alanine--D-alanine ligase	-
EU512_RS04625	943320..944675	+	1356	WP_011275264.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	936483..940659	4176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T118108 WP_011275259.1 NZ_CP035541:939620-939826 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T118108 NZ_CP035541:939620-939826 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT118108 WP_011275258.1 NZ_CP035541:939315-939608 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT118108 NZ_CP035541:939315-939608 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8