Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869608..870265 Replicon chromosome
Accession NZ_CP035540
Organism Klebsiella pneumoniae subsp. pneumoniae strain CCRI-22199

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag Kp711_RS06530 Protein ID WP_002916310.1
Coordinates 869855..870265 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag Kp711_RS06525 Protein ID WP_002916312.1
Coordinates 869608..869874 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Kp711_RS06500 864764..866197 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
Kp711_RS06505 866316..867044 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
Kp711_RS06510 867094..867405 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
Kp711_RS06515 867569..868228 + 660 WP_002916317.1 hemolysin III family protein -
Kp711_RS06520 868379..869362 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
Kp711_RS06525 869608..869874 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
Kp711_RS06530 869855..870265 + 411 WP_002916310.1 protein YgfX Toxin
Kp711_RS06535 870272..870793 - 522 WP_002916308.1 flavodoxin FldB -
Kp711_RS06540 870894..871790 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
Kp711_RS06545 871813..872526 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
Kp711_RS06550 872532..874265 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T118093 WP_002916310.1 NZ_CP035540:869855-870265 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T118093 NZ_CP035540:869855-870265 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT118093 WP_002916312.1 NZ_CP035540:869608-869874 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT118093 NZ_CP035540:869608-869874 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References