Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 16375..17188 Replicon plasmid pOT1-2
Accession NZ_CP035512
Organism Haematobacter massiliensis strain OT1

Toxin (Protein)


Gene name tacT Uniprot ID A0A494WFG0
Locus tag HmaOT1_RS15645 Protein ID WP_015740123.1
Coordinates 16679..17188 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A4P6S0J1
Locus tag HmaOT1_RS15640 Protein ID WP_066478980.1
Coordinates 16375..16674 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HmaOT1_RS15630 14158..15861 - 1704 WP_082731421.1 recombinase family protein -
HmaOT1_RS15635 15881..16105 - 225 WP_066478981.1 hypothetical protein -
HmaOT1_RS15640 16375..16674 + 300 WP_066478980.1 DUF1778 domain-containing protein Antitoxin
HmaOT1_RS15645 16679..17188 + 510 WP_015740123.1 GNAT family N-acetyltransferase Toxin
HmaOT1_RS15650 17464..18357 - 894 WP_015740125.1 3'-5' exonuclease -
HmaOT1_RS15655 18344..20374 - 2031 WP_131389674.1 ATP-binding protein -
HmaOT1_RS15660 20371..21693 - 1323 WP_131389676.1 SIR2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..349143 349143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(12-86)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 17926.66 Da        Isoelectric Point: 8.2975

>T118020 WP_015740123.1 NZ_CP035512:16679-17188 [Haematobacter massiliensis]
MLLSGPELLSAAHDVSQFSCGKPTLDHWLKTRALSNQQKGFTAVLVVHEAGRVVGYYGLAPTAVVPSVLPRSIRTGQPPN
PIPCMLLGQLATDIGSAGLGIGTGLVKHALQRCVQAASLIGGRALMVNAVDGEAAEFWQRRGFEPTRDDELVLFRSISDI
AASLREAGR

Download         Length: 510 bp

>T118020 NZ_CP035512:16679-17188 [Haematobacter massiliensis]
TTGCTGCTTTCAGGACCCGAGCTGCTTTCCGCCGCCCACGATGTTTCCCAGTTTTCCTGTGGCAAGCCGACGCTCGACCA
CTGGCTGAAGACCCGCGCGCTCTCCAATCAGCAGAAGGGCTTTACCGCCGTTCTCGTCGTGCATGAGGCAGGGCGTGTGG
TGGGATATTACGGCCTTGCACCAACAGCCGTTGTGCCATCGGTGCTACCGCGCTCCATCCGGACGGGACAGCCGCCTAAT
CCAATTCCCTGCATGCTGCTTGGTCAGCTCGCGACCGATATCGGCTCGGCCGGGTTGGGTATCGGGACTGGCCTTGTGAA
GCACGCCCTCCAACGGTGCGTTCAGGCCGCATCGCTGATCGGTGGGCGGGCATTGATGGTCAACGCCGTCGACGGGGAGG
CTGCCGAATTCTGGCAGCGCCGAGGATTTGAGCCTACCAGAGATGATGAACTGGTCCTGTTTCGCTCGATCAGCGATATT
GCTGCGTCGCTCCGTGAGGCTGGAAGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11060.78 Da        Isoelectric Point: 5.1972

>AT118020 WP_066478980.1 NZ_CP035512:16375-16674 [Haematobacter massiliensis]
MANTAERKEYPISMRLPEADVAMIDRAASLRGRSRTDFVRDAAVRAAEEVVMEQGLIRMSPEGFAQFMDVLSRPVAPVPE
MVEVLKRPAPWEPGYAAKQ

Download         Length: 300 bp

>AT118020 NZ_CP035512:16375-16674 [Haematobacter massiliensis]
ATGGCCAACACTGCCGAACGCAAGGAATATCCGATCTCAATGCGTCTGCCCGAGGCCGATGTTGCCATGATCGATCGTGC
TGCCAGCCTGCGCGGCCGCTCGCGCACCGATTTCGTGCGCGACGCCGCTGTGCGCGCGGCCGAGGAGGTCGTCATGGAGC
AGGGCCTGATCCGGATGAGCCCGGAAGGCTTTGCCCAGTTCATGGATGTGCTGTCGCGTCCGGTTGCTCCTGTTCCGGAG
ATGGTTGAAGTGCTTAAGCGGCCTGCGCCGTGGGAGCCCGGCTACGCAGCGAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A494WFG0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P6S0J1

References