Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3669501..3670200 Replicon chromosome
Accession NZ_CP035501
Organism Sphingosinicella sp. BN140058

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ETR14_RS16490 Protein ID WP_129386337.1
Coordinates 3670012..3670200 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ETR14_RS16485 Protein ID WP_129386336.1
Coordinates 3669501..3669902 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETR14_RS16435 3665005..3665715 - 711 WP_129386317.1 FkbM family methyltransferase -
ETR14_RS16440 3665791..3666489 + 699 WP_129386319.1 hypothetical protein -
ETR14_RS16445 3666532..3667008 + 477 WP_129386321.1 M15 family metallopeptidase -
ETR14_RS16450 3667005..3667271 + 267 WP_129386323.1 hypothetical protein -
ETR14_RS16455 3667329..3667538 - 210 WP_129386324.1 DUF1508 domain-containing protein -
ETR14_RS16460 3667909..3668283 - 375 WP_129386326.1 hypothetical protein -
ETR14_RS16465 3668282..3668497 + 216 WP_129386328.1 hypothetical protein -
ETR14_RS16470 3668510..3668734 + 225 WP_129386330.1 hypothetical protein -
ETR14_RS16475 3668858..3669103 - 246 WP_129386332.1 hypothetical protein -
ETR14_RS16480 3669198..3669380 - 183 WP_129386334.1 hypothetical protein -
ETR14_RS16485 3669501..3669902 - 402 WP_129386336.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ETR14_RS16490 3670012..3670200 - 189 WP_129386337.1 type II toxin-antitoxin system HicA family toxin Toxin
ETR14_RS16495 3670425..3671273 - 849 WP_129386339.1 DUF3800 domain-containing protein -
ETR14_RS16500 3672376..3674814 + 2439 WP_129391986.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3628906..3676410 47504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-120)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6947.94 Da        Isoelectric Point: 10.7735

>T118011 WP_129386337.1 NZ_CP035501:c3670200-3670012 [Sphingosinicella sp. BN140058]
MRSREVIKKIEADGWAEVRQSGSHKQFRHPTKPGTVTVPHPENDLAIGTIKSIEKQSGITLR

Download         Length: 189 bp

>T118011 NZ_CP035501:c3670200-3670012 [Sphingosinicella sp. BN140058]
ATGCGCAGCAGGGAAGTCATCAAGAAGATCGAAGCAGACGGATGGGCCGAGGTTCGCCAGTCCGGTAGCCACAAGCAGTT
CCGCCACCCGACGAAACCCGGCACGGTGACGGTACCGCACCCGGAAAACGATCTTGCGATTGGCACGATCAAGAGCATCG
AAAAGCAGAGCGGCATAACCCTTCGTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14061.80 Da        Isoelectric Point: 4.4377

>AT118011 WP_129386336.1 NZ_CP035501:c3669902-3669501 [Sphingosinicella sp. BN140058]
VATVVYPAIVERSANGYSVFFPDLPGCTSAGASLGEAFANAEEALTGHLLVAAQHGDELADPSRLEDIEYDPEIQEAGRF
LVRAEKPGKSVRLNITLDEGLVAAIDRVAKNRSGFLAEAARVALAAKRELADP

Download         Length: 402 bp

>AT118011 NZ_CP035501:c3669902-3669501 [Sphingosinicella sp. BN140058]
GTGGCAACCGTAGTTTATCCCGCGATTGTTGAGCGCAGCGCCAACGGCTATAGCGTTTTCTTTCCCGACCTTCCCGGTTG
CACCTCAGCCGGCGCCAGCCTTGGCGAAGCGTTCGCCAATGCCGAGGAGGCCCTTACCGGGCATCTGCTGGTGGCGGCTC
AGCACGGGGACGAGTTGGCTGATCCGAGCCGGCTCGAGGATATCGAGTACGATCCCGAGATCCAGGAAGCCGGGCGCTTC
CTCGTCCGTGCCGAGAAGCCGGGCAAATCGGTACGCCTCAACATCACCCTCGACGAAGGACTGGTTGCCGCGATCGACCG
GGTTGCGAAGAACCGCTCGGGCTTCCTCGCCGAAGCGGCTCGGGTCGCCCTCGCGGCCAAGCGCGAACTCGCCGACCCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References