Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3272510..3272988 Replicon chromosome
Accession NZ_CP035498
Organism Escherichia coli strain 04-00955

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag EQO00_RS16165 Protein ID WP_032351442.1
Coordinates 3272701..3272988 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag EQO00_RS16160 Protein ID WP_000100897.1
Coordinates 3272510..3272701 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQO00_RS16115 3267737..3268414 - 678 WP_064754123.1 ead/Ea22-like family protein -
EQO00_RS16120 3268374..3268679 - 306 WP_073614566.1 DUF4406 domain-containing protein -
EQO00_RS16125 3268676..3268957 - 282 WP_074431293.1 DNA-binding protein -
EQO00_RS16130 3268990..3269703 - 714 WP_086218525.1 DUF1627 domain-containing protein -
EQO00_RS16135 3269737..3270279 - 543 WP_072130322.1 replication protein -
EQO00_RS16140 3270191..3271222 - 1032 WP_001371296.1 hypothetical protein -
EQO00_RS16145 3271291..3271716 - 426 WP_000693925.1 Rha family transcriptional regulator -
EQO00_RS16150 3271700..3271972 - 273 WP_000887454.1 helix-turn-helix domain-containing protein -
EQO00_RS16155 3272081..3272482 + 402 WP_000986593.1 helix-turn-helix domain-containing protein -
EQO00_RS16160 3272510..3272701 + 192 WP_000100897.1 hypothetical protein Antitoxin
EQO00_RS16165 3272701..3272988 + 288 WP_032351442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQO00_RS16170 3273262..3273414 + 153 WP_000380312.1 DUF1391 family protein -
EQO00_RS16175 3273933..3274784 + 852 WP_086218526.1 Rha family phage regulatory protein -
EQO00_RS16180 3274795..3274983 + 189 WP_086218527.1 cell division inhibitor -
EQO00_RS16185 3274980..3275168 + 189 WP_086218528.1 DUF1482 family protein -
EQO00_RS16190 3275264..3277735 + 2472 WP_152659915.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3233431..3280108 46677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10962.84 Da        Isoelectric Point: 10.1360

>T118001 WP_032351442.1 NZ_CP035498:3272701-3272988 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHARRQFPFSI

Download         Length: 288 bp

>T118001 NZ_CP035498:3272701-3272988 [Escherichia coli]
ATGTTGCCCATTTTATGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCGCGTAGACTTAAAATACGTATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACCTATATCCACCAAGCG
AACGGGTTTCTGGGTTGAGAGAGATAGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATGCTCGCCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7013.82 Da        Isoelectric Point: 4.0270

>AT118001 WP_000100897.1 NZ_CP035498:3272510-3272701 [Escherichia coli]
MSTALSPIVSEFETIEQENSYNEWLRAKVASSLADPRPAIPHDEVIAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT118001 NZ_CP035498:3272510-3272701 [Escherichia coli]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTATCGAACAAGAAAACAGTTACAACGAATGGTTGCGCGC
TAAAGTAGCGTCAAGCCTTGCAGACCCTCGCCCCGCAATTCCACATGACGAGGTAATAGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References