Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2076038..2076869 Replicon chromosome
Accession NZ_CP035498
Organism Escherichia coli strain 04-00955

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag EQO00_RS09940 Protein ID WP_000854814.1
Coordinates 2076038..2076412 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag EQO00_RS09945 Protein ID WP_001285586.1
Coordinates 2076501..2076869 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQO00_RS09900 2071434..2072600 + 1167 WP_001519880.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
EQO00_RS09905 2072719..2073192 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
EQO00_RS09910 2073390..2074448 + 1059 WP_001200890.1 FUSC family protein -
EQO00_RS09915 2074620..2074949 + 330 WP_000450409.1 DUF496 family protein -
EQO00_RS09920 2075050..2075232 - 183 WP_001016348.1 hypothetical protein -
EQO00_RS09925 2075286..2075432 + 147 Protein_1919 transposase domain-containing protein -
EQO00_RS09930 2075721..2075834 - 114 WP_001161660.1 DUF957 domain-containing protein -
EQO00_RS09935 2075847..2076041 - 195 WP_000988601.1 hypothetical protein -
EQO00_RS09940 2076038..2076412 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
EQO00_RS09945 2076501..2076869 - 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EQO00_RS09950 2076943..2077164 - 222 WP_000692300.1 DUF987 domain-containing protein -
EQO00_RS09955 2077227..2077703 - 477 WP_001313574.1 RadC family protein -
EQO00_RS09960 2077719..2078192 - 474 WP_001313575.1 antirestriction protein -
EQO00_RS09965 2078455..2079276 - 822 WP_001234571.1 DUF945 domain-containing protein -
EQO00_RS09975 2079497..2079907 - 411 WP_000846704.1 hypothetical protein -
EQO00_RS09980 2079923..2080600 - 678 WP_001362823.1 hypothetical protein -
EQO00_RS09985 2080736..2081806 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T117989 WP_000854814.1 NZ_CP035498:c2076412-2076038 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T117989 NZ_CP035498:c2076412-2076038 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT117989 WP_001285586.1 NZ_CP035498:c2076869-2076501 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT117989 NZ_CP035498:c2076869-2076501 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References