Detailed information of TA system TA117979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2406573..2407279
• Replicon: chromosome
• Accession: NZ_CP035494
• Organism: Microbacterium protaetiae strain DFW100M-13

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ET475_RS11245
• Protein ID: WP_129390045.1
• Coordinates: 2406827..2407279 (+)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ET475_RS11240
• Protein ID: WP_129390042.1
• Coordinates: 2406573..2406830 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ET475_RS11220	2401684..2402820	+	1137	WP_129390030.1	UDP-N-acetylmuramate dehydrogenase	-
ET475_RS11225	2403081..2403383	+	303	WP_129390033.1	antibiotic biosynthesis monooxygenase	-
ET475_RS11230	2403394..2404593	-	1200	WP_207205340.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
ET475_RS11235	2404796..2406499	+	1704	WP_129390039.1	acyl-CoA dehydrogenase	-
ET475_RS11240	2406573..2406830	+	258	WP_129390042.1	antitoxin	Antitoxin
ET475_RS11245	2406827..2407279	+	453	WP_129390045.1	type II toxin-antitoxin system VapC family toxin	Toxin
ET475_RS11250	2407334..2408995	-	1662	WP_129390048.1	malate synthase A	-
ET475_RS11255	2409214..2410524	-	1311	WP_129390051.1	isocitrate lyase	-
ET475_RS11260	2410663..2412141	+	1479	WP_129390054.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-140)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 16549.72 Da
• Isoelectric Point: 6.2113

>T117979 WP_129390045.1 NZ_CP035494:2406827-2407279 [Microbacterium protaetiae]
MRVVDANVLLYAVNPATEHHTASLAWLDRALDGEDNVGFTWNALLAFVRISTNPRIMPSPADPAAAMAQVHDWLAAPSAH
VLNPGARHPEILERLLVTRGVAANLVNDAHLAAMAIEHHATIVSYDSDFDLFEGVRVNRPDDLLRNHRQR

Nucleotide

• Length: 453 bp

>T117979 NZ_CP035494:2406827-2407279 [Microbacterium protaetiae]
TTGAGAGTCGTCGACGCGAACGTGTTGCTGTACGCGGTGAACCCGGCCACCGAGCACCACACCGCATCGCTGGCCTGGCT
GGACAGGGCCCTCGACGGCGAAGACAACGTCGGGTTCACCTGGAATGCGCTGCTGGCCTTCGTTCGCATATCGACCAATC
CGCGCATCATGCCGAGCCCTGCCGACCCCGCCGCAGCAATGGCCCAGGTGCACGATTGGCTCGCCGCCCCCAGCGCTCAC
GTCCTGAACCCCGGGGCGCGGCATCCCGAAATCCTGGAGCGGCTGCTGGTCACCCGTGGCGTGGCCGCCAACCTCGTGAA
CGACGCACATCTCGCGGCGATGGCTATCGAGCATCACGCGACGATCGTCAGCTATGACAGCGACTTCGATCTCTTCGAGG
GGGTACGTGTGAACCGCCCCGACGACCTTCTGCGCAACCACAGACAGCGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9387.60 Da
• Isoelectric Point: 7.2049

>AT117979 WP_129390042.1 NZ_CP035494:2406573-2406830 [Microbacterium protaetiae]
MRTTVTLDPDTEAVVRRLMAQRGVSFKRALNDAIRAGTSPSADSEPHAYTRPRELGVPTVDLTHALRLAAESEDEELVKR
MQAGR

Nucleotide

• Length: 258 bp

>AT117979 NZ_CP035494:2406573-2406830 [Microbacterium protaetiae]
ATGCGCACCACGGTCACTCTCGACCCCGACACGGAGGCAGTGGTGCGCCGGCTGATGGCGCAGCGTGGTGTCTCGTTCAA
GCGTGCTCTCAATGATGCGATCCGAGCAGGAACCAGCCCCTCGGCGGACTCGGAGCCGCACGCCTACACGCGCCCTCGCG
AGCTCGGTGTGCCCACCGTCGACCTCACGCACGCCCTGCGGCTGGCGGCAGAGAGCGAAGACGAAGAGCTCGTCAAGCGG
ATGCAGGCCGGGCGTTGA