Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN-StbC
Location 1739577..1740205 Replicon chromosome
Accession NZ_CP035494
Organism Microbacterium protaetiae strain DFW100M-13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ET475_RS08050 Protein ID WP_129388356.1
Coordinates 1739577..1739981 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ET475_RS08055 Protein ID WP_129388359.1
Coordinates 1739978..1740205 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ET475_RS08025 1735173..1736432 - 1260 WP_129388341.1 aminotransferase class V-fold PLP-dependent enzyme -
ET475_RS08030 1736422..1737393 - 972 WP_129388344.1 hypothetical protein -
ET475_RS08035 1737395..1738255 - 861 WP_129388347.1 tryptophan 2,3-dioxygenase -
ET475_RS08040 1738385..1738708 - 324 WP_129388350.1 HEPN domain-containing protein -
ET475_RS08045 1738853..1739446 - 594 WP_129388353.1 winged helix-turn-helix domain-containing protein -
ET475_RS08050 1739577..1739981 - 405 WP_129388356.1 type II toxin-antitoxin system VapC family toxin Toxin
ET475_RS08055 1739978..1740205 - 228 WP_129388359.1 toxin-antitoxin system, antitoxin component Antitoxin
ET475_RS08060 1740396..1741904 - 1509 WP_129388362.1 HNH endonuclease -
ET475_RS08065 1742421..1742675 - 255 WP_129388365.1 NrdH-redoxin -
ET475_RS08070 1742672..1743388 - 717 WP_207205440.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
ET475_RS08075 1743454..1744398 + 945 WP_129388370.1 zinc-binding alcohol dehydrogenase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-121)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 13917.06 Da        Isoelectric Point: 5.5424

>T117978 WP_129388356.1 NZ_CP035494:c1739981-1739577 [Microbacterium protaetiae]
MIVLDASAAVEWLLGRSGARFVAERIADPDVSIHAPAPIGVEVVSALRGLTLRHHMSADRGAAAIADLAAAGVDLHDPTP
LLPRAWQLRANLSAYDAVYVALAEVLDATLLTTDARIARAPGIAAEVVVVPTGK

Download         Length: 405 bp

>T117978 NZ_CP035494:c1739981-1739577 [Microbacterium protaetiae]
ATGATCGTGCTGGATGCCTCGGCAGCAGTCGAGTGGCTGTTGGGCCGGAGTGGCGCCCGGTTCGTCGCCGAACGCATCGC
GGATCCAGATGTCTCGATCCATGCGCCCGCCCCGATCGGTGTCGAGGTGGTGTCTGCCCTGCGCGGACTCACGCTCAGGC
ACCACATGAGCGCAGATCGTGGTGCCGCCGCGATCGCCGACCTGGCTGCCGCCGGCGTCGACCTGCACGACCCCACCCCA
TTGCTTCCCCGCGCCTGGCAACTGCGCGCCAATCTGTCGGCGTACGACGCCGTGTACGTGGCACTCGCCGAGGTACTGGA
TGCCACTCTTCTCACGACGGACGCCCGCATCGCGCGGGCACCAGGCATCGCGGCCGAGGTCGTGGTCGTGCCGACGGGCA
AGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8286.50 Da        Isoelectric Point: 9.1275

>AT117978 WP_129388359.1 NZ_CP035494:c1740205-1739978 [Microbacterium protaetiae]
MTMIQIRNVPDEVHRRLKARAAMEGVSLSELALAELRRSLDRPTRAELIDLVASRESVSDGPSSVELVTAARSTR

Download         Length: 228 bp

>AT117978 NZ_CP035494:c1740205-1739978 [Microbacterium protaetiae]
ATGACAATGATCCAGATTCGCAACGTGCCCGATGAGGTGCACCGACGCCTCAAGGCGCGCGCAGCGATGGAGGGCGTGTC
ACTGTCAGAGCTCGCTTTGGCCGAGCTTCGGCGCTCCCTCGATCGGCCCACGCGCGCAGAGTTGATCGATCTCGTCGCGT
CTCGCGAGTCCGTCTCCGATGGTCCTTCTTCGGTCGAACTGGTGACCGCGGCGCGCTCGACACGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References