Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2363642..2364277 Replicon chromosome
Accession NZ_CP035492
Organism Paenibacillus protaetiae strain FW100M-2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ET464_RS11005 Protein ID WP_129440831.1
Coordinates 2363642..2363992 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag ET464_RS11010 Protein ID WP_129440833.1
Coordinates 2363996..2364277 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ET464_RS10980 2358708..2359000 - 293 Protein_2166 winged helix-turn-helix transcriptional regulator -
ET464_RS10985 2359125..2359496 - 372 WP_129440822.1 hypothetical protein -
ET464_RS10990 2359529..2361469 - 1941 WP_129440824.1 primary-amine oxidase -
ET464_RS10995 2361733..2363157 + 1425 WP_129440826.1 ammonium transporter -
ET464_RS11000 2363163..2363507 + 345 WP_129440829.1 P-II family nitrogen regulator -
ET464_RS11005 2363642..2363992 - 351 WP_129440831.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ET464_RS11010 2363996..2364277 - 282 WP_129440833.1 CopG family ribbon-helix-helix protein Antitoxin
ET464_RS11015 2364513..2365700 - 1188 WP_129444296.1 alanine racemase -
ET464_RS11020 2365848..2367041 - 1194 WP_129440835.1 outer membrane lipoprotein-sorting protein -
ET464_RS11025 2367263..2367679 - 417 WP_129440837.1 hypothetical protein -
ET464_RS11030 2367890..2369233 + 1344 WP_129440839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12796.70 Da        Isoelectric Point: 5.1171

>T117974 WP_129440831.1 NZ_CP035492:c2363992-2363642 [Paenibacillus protaetiae]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEMDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDDESMRKVDDALQISVGLIDF

Download         Length: 351 bp

>T117974 NZ_CP035492:c2363992-2363642 [Paenibacillus protaetiae]
TTGATCGTTAAACGCGGCGATGTTTTTTTTGCTGATTTGTCCCCGGTTGTTGGATCGGAGCAAGGAGGCGTCAGACCTGT
ATTGGTCATCCAGAACGACATCGGCAACCGTTTCAGCCCGACCGTTATTGTAGCGGCAATCACCGCACAAATTCAGAAAG
CCAAACTTCCGACCCACGTGGAGATGGATGCGGCGACACATGGCTTCGACAGAGATTCTGTTGTTCTGTTAGAACAAATT
CGTACGATTGATAAGCAGCGCTTAACCGATAAAATTACGCATCTCGACGATGAGTCGATGCGTAAAGTGGATGACGCCTT
GCAAATCAGCGTTGGATTAATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10693.29 Da        Isoelectric Point: 7.0158

>AT117974 WP_129440833.1 NZ_CP035492:c2364277-2363996 [Paenibacillus protaetiae]
VANIQNTKRIMISLPDQLLEEVDGIVAKENSNRSEFIRQAMKLYLVERKKRQIRESMQRGYLEMAKINLNMASEAFQAEE
EADHTLGRLVSGV

Download         Length: 282 bp

>AT117974 NZ_CP035492:c2364277-2363996 [Paenibacillus protaetiae]
GTGGCCAATATACAGAATACCAAGCGAATTATGATTAGCTTACCGGATCAATTGCTGGAAGAGGTAGACGGAATTGTCGC
AAAAGAGAATTCCAACCGCAGCGAATTTATTCGTCAAGCTATGAAATTATACTTGGTTGAACGCAAAAAACGTCAAATCC
GTGAATCGATGCAAAGAGGGTATCTGGAAATGGCCAAGATTAATTTGAACATGGCTTCGGAAGCATTTCAAGCGGAGGAA
GAGGCCGATCATACACTCGGCCGTCTTGTAAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References