Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4670509..4671046 Replicon chromosome
Accession NZ_CP035467
Organism Methylotuvimicrobium buryatense strain 5GB1C

Toxin (Protein)


Gene name relE Uniprot ID A0A4P9UUU6
Locus tag EQU24_RS20735 Protein ID WP_017841728.1
Coordinates 4670747..4671046 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P9US77
Locus tag EQU24_RS20730 Protein ID WP_017841729.1
Coordinates 4670509..4670757 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQU24_RS20695 4665933..4666877 + 945 WP_017841736.1 hypothetical protein -
EQU24_RS20700 4666899..4667144 + 246 WP_017841735.1 hypothetical protein -
EQU24_RS20705 4667353..4667709 - 357 WP_138767251.1 hypothetical protein -
EQU24_RS20710 4668360..4669367 + 1008 WP_026130284.1 fructose-bisphosphate aldolase class II -
EQU24_RS20720 4669763..4670032 - 270 WP_017841731.1 Txe/YoeB family addiction module toxin -
EQU24_RS20725 4670035..4670295 - 261 WP_017841730.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EQU24_RS20730 4670509..4670757 + 249 WP_017841729.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQU24_RS20735 4670747..4671046 + 300 WP_017841728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EQU24_RS20740 4671123..4671458 - 336 WP_083877766.1 toll/interleukin-1 receptor domain-containing protein -
EQU24_RS20745 4671694..4672086 - 393 WP_051056250.1 DUF393 domain-containing protein -
EQU24_RS20750 4672558..4674354 + 1797 WP_017841725.1 assimilatory sulfite reductase (NADPH) flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 4670035..4671374 1339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11199.14 Da        Isoelectric Point: 10.7148

>T117847 WP_017841728.1 NZ_CP035467:4670747-4671046 [Methylotuvimicrobium buryatense]
MIYELAFKKSALKEWKKLGPNVRELFAKKLKERLSSPQVPSAAVSGGTNLYKIKLRQLGYRLVYSVSDTTVTVTVLAVGK
RNRNEVYDLALSREKVDKP

Download         Length: 300 bp

>T117847 NZ_CP035467:4670747-4671046 [Methylotuvimicrobium buryatense]
ATGATCTATGAGTTAGCATTTAAGAAAAGTGCCCTGAAAGAATGGAAAAAGCTCGGTCCCAATGTACGGGAACTTTTCGC
TAAAAAACTCAAAGAGCGGCTTTCCAGTCCACAGGTTCCTTCTGCAGCAGTTAGCGGAGGAACAAACCTTTACAAAATCA
AACTGCGTCAACTTGGATATCGGCTAGTCTATTCAGTATCAGATACTACCGTCACTGTCACTGTCCTTGCCGTCGGAAAA
AGAAATCGAAATGAAGTTTATGATTTGGCTCTTTCACGCGAGAAGGTCGATAAGCCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9137.60 Da        Isoelectric Point: 4.2213

>AT117847 WP_017841729.1 NZ_CP035467:4670509-4670757 [Methylotuvimicrobium buryatense]
MTHQILTDVAASISELKANPMKVVASGEGMPIAVLNRNEPVFYCIPTKAYEAMMDLIEDKELLEIARGRMDEESIKVNLD
DL

Download         Length: 249 bp

>AT117847 NZ_CP035467:4670509-4670757 [Methylotuvimicrobium buryatense]
ATGACGCATCAAATCCTTACTGACGTGGCTGCCAGCATCTCCGAACTAAAAGCCAACCCCATGAAGGTCGTAGCCAGCGG
AGAAGGCATGCCCATTGCCGTGCTTAACAGGAATGAGCCTGTGTTTTATTGTATCCCCACCAAAGCCTATGAAGCTATGA
TGGACCTTATAGAAGATAAAGAGCTACTGGAAATTGCCAGGGGCCGCATGGACGAAGAAAGCATTAAGGTTAACCTGGAT
GATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P9UUU6

Antitoxin

Source ID Structure
AlphaFold DB A0A4P9US77

References