Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4108911..4109584 Replicon chromosome
Accession NZ_CP035467
Organism Methylotuvimicrobium buryatense strain 5GB1C

Toxin (Protein)


Gene name vapC Uniprot ID A0A4P9UTR3
Locus tag EQU24_RS18405 Protein ID WP_017842153.1
Coordinates 4108911..4109351 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4P9UR89
Locus tag EQU24_RS18410 Protein ID WP_017842152.1
Coordinates 4109351..4109584 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQU24_RS18390 4104698..4105996 + 1299 WP_138767097.1 transposase -
EQU24_RS18395 4106621..4107952 - 1332 WP_209005074.1 ISNCY family transposase -
EQU24_RS18400 4108220..4108906 - 687 WP_017842154.1 transposase -
EQU24_RS18405 4108911..4109351 - 441 WP_017842153.1 type II toxin-antitoxin system VapC family toxin Toxin
EQU24_RS18410 4109351..4109584 - 234 WP_017842152.1 DUF2191 domain-containing protein Antitoxin
EQU24_RS18415 4109740..4110024 - 285 WP_017842151.1 putative addiction module antidote protein -
EQU24_RS18420 4110035..4110328 - 294 WP_017842150.1 type II toxin-antitoxin system RelE/ParE family toxin -
EQU24_RS18425 4110464..4111021 + 558 WP_138767217.1 transposase -
EQU24_RS18430 4111417..4112844 + 1428 WP_175421704.1 IS4 family transposase -
EQU24_RS18435 4113140..4113418 - 279 WP_017842148.1 helix-turn-helix domain-containing protein -
EQU24_RS18440 4113415..4113738 - 324 WP_017842147.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16414.70 Da        Isoelectric Point: 6.5917

>T117842 WP_017842153.1 NZ_CP035467:c4109351-4108911 [Methylotuvimicrobium buryatense]
MYLLDVNILVSAHREDVAHHAAYQAWLESLLNGSGNFGYSELVLSGFLRVVTHPRIFEEPSPLSSALMFTQQIRDAQNSV
CIAPGAKHWAIFTQCLESLNACGNDVADSYHAALAMEWRCEWVSADKGFKRFKGLKWRHPATLFDC

Download         Length: 441 bp

>T117842 NZ_CP035467:c4109351-4108911 [Methylotuvimicrobium buryatense]
ATGTATTTATTGGATGTAAATATATTGGTGTCTGCGCATCGTGAGGATGTGGCGCATCATGCAGCTTATCAGGCTTGGTT
AGAGTCGTTGTTGAATGGTAGTGGCAATTTTGGTTATTCTGAGTTGGTATTAAGCGGTTTTTTGCGGGTCGTGACGCATC
CGCGTATTTTTGAAGAGCCCTCACCATTATCTAGTGCTTTGATGTTTACGCAGCAGATTAGAGACGCACAAAATTCGGTT
TGTATTGCACCAGGTGCTAAGCATTGGGCTATTTTTACCCAATGTCTGGAGAGTTTGAACGCTTGTGGTAATGACGTTGC
CGATAGCTATCATGCTGCTTTGGCTATGGAATGGCGCTGTGAATGGGTTTCTGCAGATAAGGGCTTTAAGCGTTTTAAGG
GGCTTAAATGGCGTCATCCTGCCACTTTATTCGATTGCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8308.48 Da        Isoelectric Point: 6.4476

>AT117842 WP_017842152.1 NZ_CP035467:c4109584-4109351 [Methylotuvimicrobium buryatense]
VKTSIDIDDQLLLAAKHQAVQQGCSLKQIIENALRDFVAHQEQPRPVIKLPTFGGSGLKPGVNLADSRSLNDIMDGS

Download         Length: 234 bp

>AT117842 NZ_CP035467:c4109584-4109351 [Methylotuvimicrobium buryatense]
GTGAAAACATCTATCGATATTGATGATCAATTATTATTGGCGGCTAAGCATCAAGCCGTTCAGCAGGGGTGTTCGTTAAA
ACAAATTATAGAAAATGCGTTGCGTGATTTTGTTGCGCATCAGGAACAGCCACGCCCGGTCATTAAATTACCAACGTTTG
GTGGATCAGGGTTAAAGCCGGGGGTCAATTTGGCTGATAGTCGTAGTTTGAACGATATTATGGATGGCAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P9UTR3

Antitoxin

Source ID Structure
AlphaFold DB A0A4P9UR89

References