Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3457530..3458161 Replicon chromosome
Accession NZ_CP035467
Organism Methylotuvimicrobium buryatense strain 5GB1C

Toxin (Protein)


Gene name vapC Uniprot ID A0A4P9UPY5
Locus tag EQU24_RS15430 Protein ID WP_017842736.1
Coordinates 3457530..3457916 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4P9USG9
Locus tag EQU24_RS15435 Protein ID WP_017842735.1
Coordinates 3457913..3458161 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQU24_RS15420 3453353..3455050 - 1698 WP_175421691.1 PEP-CTERM system TPR-repeat protein PrsT -
EQU24_RS15425 3456002..3456145 - 144 Protein_2901 PD-(D/E)XK nuclease family transposase -
EQU24_RS15430 3457530..3457916 - 387 WP_017842736.1 type II toxin-antitoxin system VapC family toxin Toxin
EQU24_RS15435 3457913..3458161 - 249 WP_017842735.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQU24_RS15440 3458415..3458726 - 312 WP_017842734.1 nucleotidyltransferase domain-containing protein -
EQU24_RS15445 3459004..3459378 - 375 Protein_2905 Rpn family recombination-promoting nuclease/putative transposase -
EQU24_RS15450 3459775..3460058 - 284 Protein_2906 type II toxin-antitoxin system YafQ family toxin -
EQU24_RS15455 3460045..3460308 - 264 WP_017842731.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
EQU24_RS15460 3460992..3461771 + 780 WP_017842730.1 outer membrane lipoprotein-sorting protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(4-126)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-47)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14471.75 Da        Isoelectric Point: 6.2157

>T117840 WP_017842736.1 NZ_CP035467:c3457916-3457530 [Methylotuvimicrobium buryatense]
MNLLLDTHVALWAITDNSKLSQKARELIVSPKATVWVSAANVWEIAIKHSLGRGDMPVSGRDAMRYFQESGYRFLAVEAE
HTIAVEELPLHHQDPFDRILVAQALVEPMRLMTHDPLVALYNDTIIKI

Download         Length: 387 bp

>T117840 NZ_CP035467:c3457916-3457530 [Methylotuvimicrobium buryatense]
TTGAATCTGCTGCTGGATACTCACGTTGCACTATGGGCTATCACGGATAACTCAAAACTGTCACAAAAGGCGCGTGAATT
GATTGTATCGCCCAAAGCAACCGTTTGGGTCAGCGCGGCGAATGTCTGGGAAATTGCAATCAAGCACTCACTAGGGCGAG
GCGACATGCCGGTTTCTGGCCGAGACGCGATGCGCTATTTTCAGGAATCCGGATATCGCTTCCTTGCTGTCGAGGCGGAA
CATACGATAGCGGTCGAAGAACTGCCTTTACATCACCAAGACCCGTTCGACCGCATACTTGTCGCTCAGGCGCTTGTAGA
GCCGATGCGTTTAATGACCCACGATCCTTTGGTAGCGCTCTATAACGACACAATTATCAAGATTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9039.35 Da        Isoelectric Point: 4.7405

>AT117840 WP_017842735.1 NZ_CP035467:c3458161-3457913 [Methylotuvimicrobium buryatense]
MQTVNMLQAKSSLSRLVEAIEQGQEREIVIARNGRPAAKLVPIDAAPSEKRIGVAKGLFVVPDSIDTYNDEVARLFMDEV
QN

Download         Length: 249 bp

>AT117840 NZ_CP035467:c3458161-3457913 [Methylotuvimicrobium buryatense]
ATGCAAACTGTAAATATGTTACAAGCCAAGTCTTCTCTGTCCCGCTTAGTAGAAGCCATTGAGCAAGGGCAAGAGCGAGA
AATCGTGATTGCCAGGAATGGTCGCCCAGCTGCTAAGCTTGTTCCGATAGATGCTGCGCCATCCGAGAAGCGGATTGGAG
TAGCAAAAGGCTTGTTCGTGGTGCCGGACAGCATTGATACATATAACGACGAAGTGGCTCGGTTGTTCATGGACGAGGTG
CAGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P9UPY5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P9USG9

References