Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2412546..2413111 Replicon chromosome
Accession NZ_CP035467
Organism Methylotuvimicrobium buryatense strain 5GB1C

Toxin (Protein)


Gene name vapC Uniprot ID A0A4P9UN89
Locus tag EQU24_RS10850 Protein ID WP_017839482.1
Coordinates 2412546..2412914 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4P9UN17
Locus tag EQU24_RS10855 Protein ID WP_017839481.1
Coordinates 2412917..2413111 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQU24_RS10830 2408813..2410279 + 1467 WP_138767314.1 efflux transporter outer membrane subunit -
EQU24_RS10835 2410523..2411131 - 609 WP_017839485.1 hypothetical protein -
EQU24_RS10840 2411335..2411553 - 219 WP_138767150.1 hypothetical protein -
EQU24_RS22740 2411546..2411953 - 408 WP_208976566.1 Fic family protein -
EQU24_RS22745 2412170..2412535 - 366 Protein_2031 virulence RhuM family protein -
EQU24_RS10850 2412546..2412914 - 369 WP_017839482.1 type II toxin-antitoxin system VapC family toxin Toxin
EQU24_RS10855 2412917..2413111 - 195 WP_017839481.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EQU24_RS10865 2414976..2415266 - 291 WP_026130023.1 CRISPR-associated endonuclease Cas2 -
EQU24_RS10870 2415281..2416315 - 1035 WP_014148631.1 type I-C CRISPR-associated endonuclease Cas1 -
EQU24_RS10875 2416318..2416944 - 627 WP_017839479.1 CRISPR-associated protein Cas4 -
EQU24_RS10880 2417005..2417868 - 864 WP_014148633.1 type I-C CRISPR-associated protein Cas7/Csd2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13411.70 Da        Isoelectric Point: 6.9886

>T117836 WP_017839482.1 NZ_CP035467:c2412914-2412546 [Methylotuvimicrobium buryatense]
MPILVDTSVWIDHFRKKEPALVGLLESGQVLGHPFVRGELALGHLPQRHTLLGLLDNLPQAPVAFDAEINRFIEANALFG
LGIGFVDVHLLAAAKLALNATLWTRDKRLLAVATQLTMNYQP

Download         Length: 369 bp

>T117836 NZ_CP035467:c2412914-2412546 [Methylotuvimicrobium buryatense]
ATGCCGATCTTAGTGGATACCTCGGTATGGATCGACCACTTTCGCAAAAAAGAACCTGCGTTAGTCGGTTTATTGGAAAG
CGGCCAAGTGTTAGGTCATCCGTTTGTCCGGGGTGAACTCGCGTTAGGTCATTTACCGCAACGGCATACCCTTTTGGGGT
TATTGGATAACTTGCCGCAAGCCCCGGTTGCCTTCGATGCGGAAATCAACCGGTTTATCGAAGCGAATGCCTTATTTGGT
TTAGGCATCGGTTTTGTCGATGTGCATCTGTTAGCCGCTGCAAAATTGGCGCTTAACGCTACCTTATGGACACGCGATAA
ACGCCTATTGGCCGTTGCTACGCAGCTCACTATGAACTATCAACCCTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.29 Da        Isoelectric Point: 8.7480

>AT117836 WP_017839481.1 NZ_CP035467:c2413111-2412917 [Methylotuvimicrobium buryatense]
MRTTVVLDDDLLEKAQALTNLKEKSSLIKEALKALIERESAKRLASLGGIAPDLQPIPRRQTEL

Download         Length: 195 bp

>AT117836 NZ_CP035467:c2413111-2412917 [Methylotuvimicrobium buryatense]
ATGCGCACGACGGTTGTTTTAGATGATGACTTACTCGAAAAAGCCCAAGCCTTAACCAACCTAAAAGAAAAATCCAGCCT
CATCAAAGAAGCCTTGAAGGCCCTGATTGAACGCGAGAGCGCCAAGCGCCTAGCCAGCCTGGGCGGTATTGCCCCCGATT
TGCAGCCCATCCCGCGCCGGCAAACCGAGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P9UN89

Antitoxin

Source ID Structure
AlphaFold DB A0A4P9UN17

References