Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 1801595..1802394 | Replicon | chromosome |
| Accession | NZ_CP035467 | ||
| Organism | Methylotuvimicrobium buryatense strain 5GB1C | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A4P9ULS0 |
| Locus tag | EQU24_RS08190 | Protein ID | WP_017839949.1 |
| Coordinates | 1801861..1802394 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | EQU24_RS08185 | Protein ID | WP_026130084.1 |
| Coordinates | 1801595..1801864 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EQU24_RS22720 | 1796955..1797497 | + | 543 | WP_201764846.1 | hypothetical protein | - |
| EQU24_RS22725 | 1797475..1798230 | + | 756 | WP_201764847.1 | hypothetical protein | - |
| EQU24_RS08165 | 1798788..1799963 | + | 1176 | WP_138767132.1 | transposase | - |
| EQU24_RS22345 | 1800077..1800235 | - | 159 | WP_175421670.1 | hypothetical protein | - |
| EQU24_RS08170 | 1800276..1800857 | + | 582 | WP_026130085.1 | peroxiredoxin | - |
| EQU24_RS08175 | 1800940..1801149 | + | 210 | WP_017839951.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| EQU24_RS08180 | 1801146..1801403 | + | 258 | WP_138767133.1 | type II toxin-antitoxin system HicA family toxin | - |
| EQU24_RS08185 | 1801595..1801864 | + | 270 | WP_026130084.1 | DUF1778 domain-containing protein | Antitoxin |
| EQU24_RS08190 | 1801861..1802394 | + | 534 | WP_017839949.1 | GNAT family N-acetyltransferase | Toxin |
| EQU24_RS08195 | 1802738..1804240 | + | 1503 | WP_017839948.1 | N-6 DNA methylase | - |
| EQU24_RS08200 | 1804240..1805406 | + | 1167 | WP_017839947.1 | restriction endonuclease subunit S | - |
| EQU24_RS08205 | 1805403..1805528 | + | 126 | WP_017839946.1 | hypothetical protein | - |
| EQU24_RS08210 | 1805621..1805842 | + | 222 | WP_209005077.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| EQU24_RS08215 | 1806139..1806339 | + | 201 | WP_017839943.1 | addiction module protein | - |
| EQU24_RS08220 | 1806340..1806636 | + | 297 | WP_017839942.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20010.37 Da Isoelectric Point: 9.1719
>T117834 WP_017839949.1 NZ_CP035467:1801861-1802394 [Methylotuvimicrobium buryatense]
VSWGKEFVELSKSKHDRNSFDCGVQELNTFIKTQAARHMEAGISRTMVLPSAHPLLNQQFAICAFYSVAPSSISRETLPA
QLAKKLPKYPVPVFLLAQLAVHKEFHGAGLGKVCLIRALKYLWDVNHYMRAYAIVVDCLTDSAQAFYAKFGFEVLCEHNG
RIRMFLPMKTVEQLFSQ
VSWGKEFVELSKSKHDRNSFDCGVQELNTFIKTQAARHMEAGISRTMVLPSAHPLLNQQFAICAFYSVAPSSISRETLPA
QLAKKLPKYPVPVFLLAQLAVHKEFHGAGLGKVCLIRALKYLWDVNHYMRAYAIVVDCLTDSAQAFYAKFGFEVLCEHNG
RIRMFLPMKTVEQLFSQ
Download Length: 534 bp
>T117834 NZ_CP035467:1801861-1802394 [Methylotuvimicrobium buryatense]
GTGAGTTGGGGCAAAGAGTTCGTAGAACTCAGTAAATCAAAACATGATCGCAACTCGTTTGATTGTGGCGTGCAAGAGCT
AAACACGTTTATCAAAACTCAAGCAGCAAGGCATATGGAAGCGGGGATCAGCCGCACAATGGTTTTGCCAAGTGCCCACC
CATTATTAAACCAACAGTTTGCCATTTGCGCATTTTATAGCGTTGCTCCAAGTTCAATTAGTCGTGAGACGCTGCCGGCA
CAACTTGCTAAAAAACTTCCTAAATATCCGGTACCTGTTTTCTTGCTTGCACAATTAGCGGTGCATAAAGAGTTTCATGG
TGCGGGACTTGGTAAAGTTTGCCTTATTCGCGCGTTGAAATACTTGTGGGATGTGAACCATTATATGAGAGCTTATGCAA
TTGTTGTCGACTGCTTGACCGATTCAGCACAAGCCTTTTATGCGAAGTTCGGCTTCGAGGTCTTGTGTGAACACAATGGA
CGCATCCGTATGTTCTTACCGATGAAAACGGTAGAACAGCTTTTCAGCCAATAG
GTGAGTTGGGGCAAAGAGTTCGTAGAACTCAGTAAATCAAAACATGATCGCAACTCGTTTGATTGTGGCGTGCAAGAGCT
AAACACGTTTATCAAAACTCAAGCAGCAAGGCATATGGAAGCGGGGATCAGCCGCACAATGGTTTTGCCAAGTGCCCACC
CATTATTAAACCAACAGTTTGCCATTTGCGCATTTTATAGCGTTGCTCCAAGTTCAATTAGTCGTGAGACGCTGCCGGCA
CAACTTGCTAAAAAACTTCCTAAATATCCGGTACCTGTTTTCTTGCTTGCACAATTAGCGGTGCATAAAGAGTTTCATGG
TGCGGGACTTGGTAAAGTTTGCCTTATTCGCGCGTTGAAATACTTGTGGGATGTGAACCATTATATGAGAGCTTATGCAA
TTGTTGTCGACTGCTTGACCGATTCAGCACAAGCCTTTTATGCGAAGTTCGGCTTCGAGGTCTTGTGTGAACACAATGGA
CGCATCCGTATGTTCTTACCGATGAAAACGGTAGAACAGCTTTTCAGCCAATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 9757.15 Da Isoelectric Point: 4.7341
>AT117834 WP_026130084.1 NZ_CP035467:1801595-1801864 [Methylotuvimicrobium buryatense]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLINEDATHVIEKHESIAVKDSVFDEFIAACDKAKAPNRALLDAA
KFAEESGIE
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLINEDATHVIEKHESIAVKDSVFDEFIAACDKAKAPNRALLDAA
KFAEESGIE
Download Length: 270 bp
>AT117834 NZ_CP035467:1801595-1801864 [Methylotuvimicrobium buryatense]
ATGGCTACAGCTCGTTTAGATATTCGACTTGACGAAGAAATCAAGGCTAAAGCGGAAAAAGCTTCAGCTTTGCTTGGGTT
AAAAAGCCTAACAGAGTACGTTGTTAGGCTAATAAACGAAGACGCAACTCATGTTATTGAAAAACATGAAAGTATTGCAG
TCAAAGACAGTGTGTTTGATGAATTTATTGCAGCGTGTGATAAAGCAAAAGCGCCCAACCGAGCTCTACTGGATGCTGCT
AAATTTGCAGAAGAGAGCGGCATTGAGTGA
ATGGCTACAGCTCGTTTAGATATTCGACTTGACGAAGAAATCAAGGCTAAAGCGGAAAAAGCTTCAGCTTTGCTTGGGTT
AAAAAGCCTAACAGAGTACGTTGTTAGGCTAATAAACGAAGACGCAACTCATGTTATTGAAAAACATGAAAGTATTGCAG
TCAAAGACAGTGTGTTTGATGAATTTATTGCAGCGTGTGATAAAGCAAAAGCGCCCAACCGAGCTCTACTGGATGCTGCT
AAATTTGCAGAAGAGAGCGGCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|