Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1133068..1133576 Replicon chromosome
Accession NZ_CP035467
Organism Methylotuvimicrobium buryatense strain 5GB1C

Toxin (Protein)


Gene name relE Uniprot ID A0A4V1IJK6
Locus tag EQU24_RS05330 Protein ID WP_017840484.1
Coordinates 1133316..1133576 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P9UKK4
Locus tag EQU24_RS05325 Protein ID WP_017840485.1
Coordinates 1133068..1133319 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQU24_RS05305 1129474..1129971 - 498 WP_017840489.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -
EQU24_RS05310 1129968..1131371 - 1404 WP_017840488.1 cobyric acid synthase -
EQU24_RS05315 1131368..1131931 - 564 WP_017840487.1 alpha-ribazole phosphatase -
EQU24_RS05320 1131916..1132662 - 747 WP_017840486.1 adenosylcobinamide-GDP ribazoletransferase -
EQU24_RS05325 1133068..1133319 + 252 WP_017840485.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EQU24_RS05330 1133316..1133576 + 261 WP_017840484.1 Txe/YoeB family addiction module toxin Toxin
EQU24_RS05335 1133717..1135075 - 1359 WP_017840483.1 hypothetical protein -
EQU24_RS05340 1135059..1135430 - 372 WP_201764853.1 hypothetical protein -
EQU24_RS05345 1135605..1136009 - 405 WP_138767088.1 hypothetical protein -
EQU24_RS05350 1136685..1137032 - 348 WP_083877693.1 DUF29 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10416.96 Da        Isoelectric Point: 9.8039

>T117833 WP_017840484.1 NZ_CP035467:1133316-1133576 [Methylotuvimicrobium buryatense]
MNLTFSSVSWENYLYRQKTDKAMLKRINSLLKAIQREPFEGIGKPEPLKHGLSGYWSRRINDEHRLVYKVVEDHIFIAQL
RYHYEY

Download         Length: 261 bp

>T117833 NZ_CP035467:1133316-1133576 [Methylotuvimicrobium buryatense]
ATGAATCTGACTTTTTCCAGCGTATCTTGGGAAAACTACTTGTACCGGCAAAAAACCGATAAGGCCATGCTTAAACGAAT
AAATTCTTTGCTTAAGGCTATTCAGCGCGAACCTTTTGAAGGTATCGGTAAACCTGAGCCGTTGAAGCACGGTTTGTCCG
GCTATTGGTCTCGACGCATTAACGATGAACACCGGCTTGTCTATAAAGTTGTTGAAGACCATATTTTTATCGCTCAGCTT
CGCTATCACTACGAGTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9388.56 Da        Isoelectric Point: 4.5023

>AT117833 WP_017840485.1 NZ_CP035467:1133068-1133319 [Methylotuvimicrobium buryatense]
MDAISYTTARANLAKTMEKVCNDHDPVIITRKREAPVVMISLEDFQSMEETAYQLRSPANARHLLESIAELEAGNGTEHE
WIE

Download         Length: 252 bp

>AT117833 NZ_CP035467:1133068-1133319 [Methylotuvimicrobium buryatense]
ATGGACGCCATAAGCTACACCACTGCACGAGCTAACCTAGCGAAAACTATGGAAAAGGTTTGTAATGACCACGATCCCGT
GATTATTACCCGAAAGAGAGAAGCGCCTGTAGTCATGATTTCTTTAGAAGACTTTCAGTCCATGGAAGAAACAGCATACC
AGCTTCGATCCCCTGCAAATGCTCGCCACCTACTAGAGTCGATTGCAGAACTTGAGGCTGGGAACGGTACCGAGCACGAG
TGGATAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V1IJK6

Antitoxin

Source ID Structure
AlphaFold DB A0A4P9UKK4

References