Detailed information of TA system TA117832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/StbC(antitoxin)
• Location: 904896..905391
• Replicon: chromosome
• Accession: NZ_CP035467
• Organism: Methylotuvimicrobium buryatense strain 5GB1C

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EQU24_RS04310
• Protein ID: WP_017840680.1
• Coordinates: 904896..905168 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A4P9UK09
• Locus tag: EQU24_RS04315
• Protein ID: WP_017840679.1
• Coordinates: 905155..905391 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EQU24_RS04285	901233..901607	+	375	WP_026130165.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EQU24_RS04290	901648..901917	+	270	WP_208976567.1	helix-turn-helix domain-containing protein	-
EQU24_RS04295	902378..902659	-	282	WP_017840683.1	putative addiction module antidote protein	-
EQU24_RS04300	902711..902963	-	253	Protein_810	type II toxin-antitoxin system RelE/ParE family toxin	-
EQU24_RS04305	903212..904102	+	891	WP_017840681.1	DUF4351 domain-containing protein	-
EQU24_RS04310	904896..905168	-	273	WP_017840680.1	PIN domain-containing protein	Toxin
EQU24_RS04315	905155..905391	-	237	WP_017840679.1	DNA-binding protein	Antitoxin
EQU24_RS04320	905722..905976	+	255	Protein_814	BrnT family toxin	-
EQU24_RS04325	905981..906256	+	276	WP_017840678.1	BrnA antitoxin family protein	-
EQU24_RS04330	906786..907343	+	558	WP_017840676.1	Uma2 family endonuclease	-
EQU24_RS04335	907996..908865	+	870	WP_040575631.1	glycosyltransferase family 2 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10331.79 Da
• Isoelectric Point: 4.2813

>T117832 WP_017840680.1 NZ_CP035467:c905168-904896 [Methylotuvimicrobium buryatense]
MYLIDTNIISELRKGYKANSGVQEFFDKVIQENVPIYISAITIGELRRGVDLIFHRGDETQGKLLENWLNSILDQYQDNI
LAIDSEIAML

Nucleotide

• Length: 273 bp

>T117832 NZ_CP035467:c905168-904896 [Methylotuvimicrobium buryatense]
ATGTATTTGATTGATACCAACATCATCAGCGAGCTTAGAAAAGGCTATAAAGCTAATTCCGGTGTGCAAGAATTTTTCGA
TAAAGTCATTCAGGAGAATGTCCCCATTTACATTTCCGCCATTACGATTGGCGAATTGCGCAGAGGCGTCGATTTGATTT
TCCACCGTGGCGACGAAACACAAGGCAAACTGTTGGAAAACTGGCTCAATAGCATCCTCGATCAATATCAAGACAACATC
CTAGCCATTGATAGCGAAATTGCTATGCTTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8774.84 Da
• Isoelectric Point: 5.5882

>AT117832 WP_017840679.1 NZ_CP035467:c905391-905155 [Methylotuvimicrobium buryatense]
MPSLVVRNLDDSIINALKERAVKHHRSTEAEHRAILAEVLMKPQRKSFAEALANIPTVGTDTDFQRINDDTSESNVFD

Nucleotide

• Length: 237 bp

>AT117832 NZ_CP035467:c905391-905155 [Methylotuvimicrobium buryatense]
ATGCCAAGTCTAGTCGTTAGAAACCTTGATGATTCAATCATAAATGCGTTGAAAGAAAGAGCGGTTAAACACCATCGCTC
TACTGAAGCCGAGCATCGAGCCATTTTGGCTGAAGTCCTGATGAAACCTCAACGTAAAAGCTTTGCTGAAGCTTTAGCCA
ACATACCTACTGTTGGCACGGATACGGATTTTCAGCGCATCAATGACGATACTAGCGAATCCAATGTATTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A4P9UK09