Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2504369..2504988 Replicon chromosome
Accession NZ_CP035466
Organism Klebsiella aerogenes strain LU2

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag ES159_RS12140 Protein ID WP_015367918.1
Coordinates 2504369..2504587 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag ES159_RS12145 Protein ID WP_015367917.1
Coordinates 2504614..2504988 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES159_RS12105 2500433..2500693 + 261 WP_015367923.1 type B 50S ribosomal protein L31 -
ES159_RS12110 2500696..2500836 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ES159_RS12115 2500833..2501552 - 720 WP_142961950.1 GNAT family N-acetyltransferase -
ES159_RS12120 2501655..2503109 + 1455 WP_047739993.1 PLP-dependent aminotransferase family protein -
ES159_RS12125 2503084..2503548 - 465 WP_015367920.1 YlaC family protein -
ES159_RS12135 2503674..2504237 - 564 WP_142961951.1 maltose O-acetyltransferase -
ES159_RS12140 2504369..2504587 - 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
ES159_RS12145 2504614..2504988 - 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
ES159_RS12150 2505461..2508607 - 3147 WP_015704610.1 multidrug efflux RND transporter permease subunit -
ES159_RS12155 2508630..2509829 - 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2495694..2504988 9294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T117819 WP_015367918.1 NZ_CP035466:c2504587-2504369 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T117819 NZ_CP035466:c2504587-2504369 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT117819 WP_015367917.1 NZ_CP035466:c2504988-2504614 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT117819 NZ_CP035466:c2504988-2504614 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGACGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References