Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2504369..2504988 Replicon chromosome
Accession NZ_CP035466
Organism Klebsiella aerogenes strain LU2

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag ES159_RS12140 Protein ID WP_015367918.1
Coordinates 2504369..2504587 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag ES159_RS12145 Protein ID WP_015367917.1
Coordinates 2504614..2504988 (-) Length 125 a.a.

Genomic Context

ES159_RS12105ES159_RS12110ES159_RS12120ES159_RS12115ES159_RS12125ES159_RS12135ES159_RS12140ES159_RS12145ES159_RS12150ES159_RS12155
Location: 2500433..2500693 (261 bp)
Type: Others
Protein ID: WP_015367923.1
Location: 2500696..2500836 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 2501655..2503109 (1455 bp)
Type: Others
Protein ID: WP_047739993.1
Location: 2500833..2501552 (720 bp)
Type: Others
Protein ID: WP_142961950.1
Location: 2503084..2503548 (465 bp)
Type: Others
Protein ID: WP_015367920.1
Location: 2503674..2504237 (564 bp)
Type: Others
Protein ID: WP_142961951.1
Location: 2504369..2504587 (219 bp)
Type: Toxin
Protein ID: WP_015367918.1
Location: 2504614..2504988 (375 bp)
Type: Antitoxin
Protein ID: WP_015367917.1
Location: 2505461..2508607 (3147 bp)
Type: Others
Protein ID: WP_015704610.1
Location: 2508630..2509829 (1200 bp)
Type: Others
Protein ID: WP_020079451.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ES159_RS121052500433..2500693+261WP_015367923.1type B 50S ribosomal protein L31-
ES159_RS121102500696..2500836+141WP_003859006.1type B 50S ribosomal protein L36-
ES159_RS121152500833..2501552-720WP_142961950.1GNAT family N-acetyltransferase-
ES159_RS121202501655..2503109+1455WP_047739993.1PLP-dependent aminotransferase family protein-
ES159_RS121252503084..2503548-465WP_015367920.1YlaC family protein-
ES159_RS121352503674..2504237-564WP_142961951.1maltose O-acetyltransferase-
ES159_RS121402504369..2504587-219WP_015367918.1hemolysin expression modulator HhaToxin
ES159_RS121452504614..2504988-375WP_015367917.1Hha toxicity modulator TomBAntitoxin
ES159_RS121502505461..2508607-3147WP_015704610.1multidrug efflux RND transporter permease subunit-
ES159_RS121552508630..2509829-1200WP_020079451.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--2495694..25049889294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T117819 WP_015367918.1 NZ_CP035466:c2504587-2504369 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T117819 NZ_CP035466:c2504587-2504369 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT117819 WP_015367917.1 NZ_CP035466:c2504988-2504614 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT117819 NZ_CP035466:c2504988-2504614 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGACGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3FXE2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3FPM3

References