Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 921635..922221 Replicon chromosome
Accession NZ_CP035466
Organism Klebsiella aerogenes strain LU2

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag ES159_RS04660 Protein ID WP_002920800.1
Coordinates 921635..922003 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag ES159_RS04665 Protein ID WP_004174006.1
Coordinates 922000..922221 (-) Length 74 a.a.

Genomic Context

ES159_RS04640ES159_RS04645ES159_RS04650ES159_RS04655ES159_RS04660ES159_RS04665ES159_RS04670ES159_RS04675ES159_RS04680ES159_RS04685
Location: 917119..918189 (1071 bp)
Type: Others
Protein ID: WP_049035288.1
Location: 918191..919036 (846 bp)
Type: Others
Protein ID: WP_015369329.1
Location: 919033..919920 (888 bp)
Type: Others
Protein ID: WP_045375777.1
Location: 920027..921343 (1317 bp)
Type: Others
Protein ID: WP_049035282.1
Location: 921635..922003 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 922000..922221 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 922385..923098 (714 bp)
Type: Others
Protein ID: WP_086538103.1
Location: 923116..923883 (768 bp)
Type: Others
Protein ID: WP_015369325.1
Location: 923880..925157 (1278 bp)
Type: Others
Protein ID: WP_015369324.1
Location: 925154..926080 (927 bp)
Type: Others
Protein ID: WP_015369323.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ES159_RS04640917119..918189-1071WP_049035288.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-
ES159_RS04645918191..919036-846WP_015369329.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
ES159_RS04650919033..919920-888WP_045375777.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
ES159_RS04655920027..921343-1317WP_049035282.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
ES159_RS04660921635..922003-369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
ES159_RS04665922000..922221-222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ES159_RS04670922385..923098-714WP_086538103.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
ES159_RS04675923116..923883-768WP_015369325.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
ES159_RS04680923880..925157-1278WP_015369324.1branched chain amino acid ABC transporter permease LivM-
ES159_RS04685925154..926080-927WP_015369323.1high-affinity branched-chain amino acid ABC transporter permease LivH-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--916382..93248116099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T117818 WP_002920800.1 NZ_CP035466:c922003-921635 [Klebsiella aerogenes]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T117818 NZ_CP035466:c922003-921635 [Klebsiella aerogenes]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT117818 WP_004174006.1 NZ_CP035466:c922221-922000 [Klebsiella aerogenes]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT117818 NZ_CP035466:c922221-922000 [Klebsiella aerogenes]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GUD1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References