Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 381735..382392 Replicon chromosome
Accession NZ_CP035466
Organism Klebsiella aerogenes strain LU2

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag ES159_RS01960 Protein ID WP_015369792.1
Coordinates 381735..382145 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag ES159_RS01965 Protein ID WP_015369791.1
Coordinates 382126..382392 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES159_RS01940 377734..379467 - 1734 WP_032715785.1 single-stranded-DNA-specific exonuclease RecJ -
ES159_RS01945 379473..380186 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ES159_RS01950 380209..381105 - 897 WP_045414365.1 site-specific tyrosine recombinase XerD -
ES159_RS01955 381206..381727 + 522 WP_045387211.1 flavodoxin FldB -
ES159_RS01960 381735..382145 - 411 WP_015369792.1 protein YgfX Toxin
ES159_RS01965 382126..382392 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
ES159_RS01970 382616..383599 + 984 WP_015369790.1 tRNA-modifying protein YgfZ -
ES159_RS01975 383854..384513 - 660 WP_008806429.1 hemolysin III family protein -
ES159_RS01980 384678..384989 - 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
ES159_RS01985 385040..385774 + 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
ES159_RS01990 385888..387321 + 1434 WP_047053696.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T117817 WP_015369792.1 NZ_CP035466:c382145-381735 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T117817 NZ_CP035466:c382145-381735 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGTATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT117817 WP_015369791.1 NZ_CP035466:c382392-382126 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT117817 NZ_CP035466:c382392-382126 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References