Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1455888..1456437 Replicon chromosome
Accession NZ_CP035464
Organism Bifidobacterium pullorum subsp. gallinarum strain CACC 514

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ESN35_RS06185 Protein ID WP_129237470.1
Coordinates 1455888..1456208 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ESN35_RS06190 Protein ID WP_129237471.1
Coordinates 1456195..1456437 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESN35_RS06150 1450944..1451660 + 717 WP_129237457.1 hypothetical protein -
ESN35_RS06155 1451680..1452144 + 465 WP_129237459.1 hypothetical protein -
ESN35_RS06160 1452150..1452863 + 714 WP_129237461.1 hypothetical protein -
ESN35_RS06165 1452863..1453705 + 843 WP_129237462.1 hypothetical protein -
ESN35_RS06170 1453782..1454846 + 1065 WP_164999762.1 antirestriction protein ArdA -
ESN35_RS06175 1454863..1455198 + 336 WP_129237466.1 hypothetical protein -
ESN35_RS06180 1455195..1455875 + 681 WP_129237468.1 hypothetical protein -
ESN35_RS06185 1455888..1456208 - 321 WP_129237470.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ESN35_RS06190 1456195..1456437 - 243 WP_129237471.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ESN35_RS06195 1456578..1456892 + 315 WP_129237473.1 hypothetical protein -
ESN35_RS06200 1456889..1458199 + 1311 WP_129237475.1 HipA domain-containing protein -
ESN35_RS06205 1458255..1459193 - 939 WP_129238344.1 tyrosine-type recombinase/integrase -
ESN35_RS06210 1459514..1460356 - 843 WP_129237476.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1439401..1459193 19792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11737.60 Da        Isoelectric Point: 9.2175

>T117815 WP_129237470.1 NZ_CP035464:c1456208-1455888 [Bifidobacterium pullorum subsp. gallinarum]
MRRGEIWSVAGRGYAAKPRPVLVVQSDGTLPSYDSVVVCLLTSVDRDDACRVRIENLPETGLKRESWVMADKILAVRKDE
LGSRIGRLPDAEMTRVSQALRTVLGL

Download         Length: 321 bp

>T117815 NZ_CP035464:c1456208-1455888 [Bifidobacterium pullorum subsp. gallinarum]
ATGAGACGCGGTGAGATCTGGAGCGTGGCCGGCCGCGGCTACGCCGCGAAGCCCCGCCCCGTGCTGGTCGTCCAGTCCGA
CGGCACGCTGCCATCTTATGACTCCGTCGTGGTCTGCCTGCTCACCTCGGTGGACCGTGACGACGCATGCCGCGTCCGGA
TCGAGAACCTGCCGGAAACGGGATTGAAACGCGAAAGCTGGGTCATGGCGGACAAGATTCTCGCGGTCCGTAAGGACGAG
CTCGGATCCCGGATCGGTCGGCTGCCCGACGCCGAGATGACCCGGGTCTCCCAGGCGCTCAGAACCGTCCTCGGACTCTG
A

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8986.97 Da        Isoelectric Point: 4.3569

>AT117815 WP_129237471.1 NZ_CP035464:c1456437-1456195 [Bifidobacterium pullorum subsp. gallinarum]
MTIQVSTRVSDQQAEQFRDTAARLGTTASDVLRMFITSFNAAGGFPYAVRVRQDAEPFDSEREATDFADAMSMRMLDETR

Download         Length: 243 bp

>AT117815 NZ_CP035464:c1456437-1456195 [Bifidobacterium pullorum subsp. gallinarum]
ATGACCATCCAGGTTTCCACACGGGTGAGCGACCAGCAGGCGGAGCAGTTCAGGGACACGGCCGCGCGATTGGGGACGAC
CGCGTCCGACGTGCTGCGCATGTTCATCACCAGCTTCAACGCGGCCGGCGGGTTCCCCTACGCGGTTCGCGTCCGGCAGG
ACGCGGAGCCCTTCGACTCCGAACGGGAGGCCACGGACTTCGCCGACGCCATGAGCATGAGGATGCTCGATGAGACGCGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References