Detailed information of TA system TA117810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1569878..1570490
• Replicon: chromosome
• Accession: NZ_CP035455
• Organism: Streptococcus pyogenes strain emm197

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT44_RS08200
• Protein ID: WP_014635711.1
• Coordinates: 1570155..1570490 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT44_RS08195
• Protein ID: WP_002988079.1
• Coordinates: 1569878..1570165 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT44_RS08170	1565069..1566052	-	984	WP_136021875.1	tagatose-bisphosphate aldolase	-
ETT44_RS08175	1566056..1566985	-	930	WP_136021874.1	tagatose-6-phosphate kinase	-
ETT44_RS08180	1567031..1567546	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
ETT44_RS08185	1567581..1568009	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
ETT44_RS08190	1568455..1569228	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT44_RS08195	1569878..1570165	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT44_RS08200	1570155..1570490	+	336	WP_014635711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT44_RS08205	1570579..1571623	+	1045	Protein_1506	site-specific integrase	-
ETT44_RS08210	1571743..1572135	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT44_RS08215	1572156..1572602	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT44_RS08220	1572820..1573026	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT44_RS08225	1573023..1573529	-	507	WP_002988070.1	hypothetical protein	-
ETT44_RS08230	1573665..1574525	-	861	WP_002982687.1	DegV family protein	-
ETT44_RS08235	1574622..1575140	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13173.94 Da
• Isoelectric Point: 5.6809

>T117810 WP_014635711.1 NZ_CP035455:1570155-1570490 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T117810 NZ_CP035455:1570155-1570490 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117810 WP_002988079.1 NZ_CP035455:1569878-1570165 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117810 NZ_CP035455:1569878-1570165 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94