Detailed information of TA system TA117809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1511272..1511884
• Replicon: chromosome
• Accession: NZ_CP035454
• Organism: Streptococcus pyogenes strain emm54

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT45_RS07690
• Protein ID: WP_023080134.1
• Coordinates: 1511549..1511884 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT45_RS07685
• Protein ID: WP_002988079.1
• Coordinates: 1511272..1511559 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT45_RS07660	1506463..1507446	-	984	WP_030126795.1	tagatose-bisphosphate aldolase	-
ETT45_RS07665	1507450..1508379	-	930	WP_030126796.1	tagatose-6-phosphate kinase	-
ETT45_RS07670	1508425..1508940	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
ETT45_RS07675	1508975..1509403	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
ETT45_RS07680	1509849..1510622	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT45_RS07685	1511272..1511559	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT45_RS07690	1511549..1511884	+	336	WP_023080134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT45_RS08855	1512036..1512506	+	471	Protein_1412	integrase	-
ETT45_RS07705	1512469..1513017	+	549	WP_109828874.1	site-specific integrase	-
ETT45_RS07710	1513137..1513529	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT45_RS07715	1513550..1513996	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT45_RS07720	1514214..1514420	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT45_RS07725	1514417..1514923	-	507	WP_002988070.1	hypothetical protein	-
ETT45_RS07730	1515059..1515919	-	861	WP_002982687.1	DegV family protein	-
ETT45_RS07735	1516016..1516534	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13159.91 Da
• Isoelectric Point: 5.2233

>T117809 WP_023080134.1 NZ_CP035454:1511549-1511884 [Streptococcus pyogenes]
MDYKKYQIIYAPEVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117809 NZ_CP035454:1511549-1511884 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGAAGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117809 WP_002988079.1 NZ_CP035454:1511272-1511559 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117809 NZ_CP035454:1511272-1511559 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94