Detailed information of TA system TA117808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1595291..1595903
• Replicon: chromosome
• Accession: NZ_CP035453
• Organism: Streptococcus pyogenes strain emm100

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT46_RS08270
• Protein ID: WP_002994716.1
• Coordinates: 1595568..1595903 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT46_RS08265
• Protein ID: WP_002988079.1
• Coordinates: 1595291..1595578 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT46_RS08240	1590483..1591466	-	984	WP_111702287.1	tagatose-bisphosphate aldolase	-
ETT46_RS08245	1591470..1592399	-	930	WP_136047938.1	tagatose-6-phosphate kinase	-
ETT46_RS08250	1592445..1592960	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
ETT46_RS08255	1592995..1593423	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
ETT46_RS08260	1593868..1594641	+	774	WP_023605292.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT46_RS08265	1595291..1595578	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT46_RS08270	1595568..1595903	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT46_RS09545	1596055..1596525	+	471	WP_021733374.1	site-specific integrase	-
ETT46_RS09550	1596488..1597036	+	549	WP_136115776.1	site-specific integrase	-
ETT46_RS08280	1597156..1597548	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT46_RS08285	1597569..1598015	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT46_RS08290	1598233..1598439	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT46_RS08295	1598436..1598942	-	507	WP_002988070.1	hypothetical protein	-
ETT46_RS08300	1599078..1599938	-	861	WP_002982687.1	DegV family protein	-
ETT46_RS08305	1600035..1600553	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T117808 WP_002994716.1 NZ_CP035453:1595568-1595903 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T117808 NZ_CP035453:1595568-1595903 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117808 WP_002988079.1 NZ_CP035453:1595291-1595578 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117808 NZ_CP035453:1595291-1595578 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94