Detailed information of TA system TA117806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1595386..1595998
• Replicon: chromosome
• Accession: NZ_CP035451
• Organism: Streptococcus pyogenes strain emm230

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT48_RS08245
• Protein ID: WP_002994716.1
• Coordinates: 1595663..1595998 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT48_RS08240
• Protein ID: WP_002988079.1
• Coordinates: 1595386..1595673 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT48_RS08215	1590578..1591561	-	984	WP_002991696.1	tagatose-bisphosphate aldolase	-
ETT48_RS08220	1591565..1592494	-	930	WP_002991698.1	tagatose-6-phosphate kinase	-
ETT48_RS08225	1592540..1593055	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
ETT48_RS08230	1593090..1593518	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
ETT48_RS08235	1593963..1594736	+	774	WP_002993783.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT48_RS08240	1595386..1595673	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT48_RS08245	1595663..1595998	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT48_RS09395	1596150..1596620	+	471	WP_033888285.1	tyrosine-type recombinase/integrase family protein	-
ETT48_RS09400	1596583..1597131	+	549	WP_186798019.1	site-specific integrase	-
ETT48_RS08255	1597251..1597643	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT48_RS08260	1597664..1598110	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT48_RS08265	1598328..1598534	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT48_RS08270	1598531..1599037	-	507	WP_002994536.1	hypothetical protein	-
ETT48_RS08275	1599173..1600033	-	861	WP_002982687.1	DegV family protein	-
ETT48_RS08280	1600130..1600648	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T117806 WP_002994716.1 NZ_CP035451:1595663-1595998 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T117806 NZ_CP035451:1595663-1595998 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117806 WP_002988079.1 NZ_CP035451:1595386-1595673 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117806 NZ_CP035451:1595386-1595673 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94