Detailed information of TA system TA117805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1461208..1461820
• Replicon: chromosome
• Accession: NZ_CP035450
• Organism: Streptococcus pyogenes strain emm93.4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ETT49_RS07355
• Protein ID: WP_136047939.1
• Coordinates: 1461485..1461820 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT49_RS07350
• Protein ID: WP_002988079.1
• Coordinates: 1461208..1461495 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT49_RS07325	1456388..1457371	-	984	WP_011529001.1	tagatose-bisphosphate aldolase	-
ETT49_RS07330	1457375..1458304	-	930	WP_136269240.1	tagatose-6-phosphate kinase	-
ETT49_RS07335	1458350..1458865	-	516	WP_011285170.1	galactose-6-phosphate isomerase subunit LacB	-
ETT49_RS07340	1458900..1459328	-	429	WP_023078895.1	galactose-6-phosphate isomerase subunit LacA	-
ETT49_RS07345	1459774..1460547	+	774	WP_136269242.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT49_RS07350	1461208..1461495	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT49_RS07355	1461485..1461820	+	336	WP_136047939.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT49_RS08560	1461972..1462442	+	471	WP_021733374.1	site-specific integrase	-
ETT49_RS08565	1462405..1462953	+	549	WP_136115776.1	site-specific integrase	-
ETT49_RS07365	1463073..1463465	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT49_RS07370	1463486..1463932	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT49_RS07375	1464150..1464356	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT49_RS07380	1464353..1464859	-	507	WP_186793260.1	hypothetical protein	-
ETT49_RS07385	1464995..1465855	-	861	WP_002982687.1	DegV family protein	-
ETT49_RS07390	1465952..1466470	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13184.92 Da
• Isoelectric Point: 5.6157

>T117805 WP_136047939.1 NZ_CP035450:1461485-1461820 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDTDEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T117805 NZ_CP035450:1461485-1461820 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATACTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117805 WP_002988079.1 NZ_CP035450:1461208-1461495 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117805 NZ_CP035450:1461208-1461495 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94