Detailed information of TA system TA117804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1599115..1599727
• Replicon: chromosome
• Accession: NZ_CP035449
• Organism: Streptococcus pyogenes strain emm56

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: ETT50_RS08305
• Protein ID: WP_002982731.1
• Coordinates: 1599392..1599727 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: ETT50_RS08300
• Protein ID: WP_002988079.1
• Coordinates: 1599115..1599402 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETT50_RS08275	1594304..1595287	-	984	WP_011529001.1	tagatose-bisphosphate aldolase	-
ETT50_RS08280	1595291..1596220	-	930	WP_032465238.1	tagatose-6-phosphate kinase	-
ETT50_RS08285	1596268..1596783	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
ETT50_RS08290	1596818..1597246	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
ETT50_RS08295	1597692..1598465	+	774	WP_032465239.1	DeoR/GlpR family DNA-binding transcription regulator	-
ETT50_RS08300	1599115..1599402	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
ETT50_RS08305	1599392..1599727	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETT50_RS09460	1599878..1600348	+	471	Protein_1532	integrase	-
ETT50_RS09465	1600624..1600860	+	237	WP_186788718.1	tyrosine-type recombinase/integrase	-
ETT50_RS08325	1600992..1601384	-	393	WP_002982716.1	30S ribosomal protein S9	-
ETT50_RS08330	1601405..1601851	-	447	WP_002982710.1	50S ribosomal protein L13	-
ETT50_RS08335	1602069..1602275	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
ETT50_RS08340	1602272..1602970	-	699	WP_032465241.1	hypothetical protein	-
ETT50_RS08345	1603106..1603966	-	861	WP_032465242.1	DegV family protein	-
ETT50_RS08350	1604063..1604581	-	519	WP_032465243.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T117804 WP_002982731.1 NZ_CP035449:1599392-1599727 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T117804 NZ_CP035449:1599392-1599727 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT117804 WP_002988079.1 NZ_CP035449:1599115-1599402 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT117804 NZ_CP035449:1599115-1599402 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A4U7GX94